90-54-0
Chemical Structure
Etafenone
- CAS. Nr.: 90-54-0
- Formula:C21H27NO2
- Molecular Weight:325.44
IUPAC Name: 1-(2-(2-(diethylamino)ethoxy)phenyl)-3-phenylpropan-1-one
InChIKey: OEGDFSLNGABBKJ-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CC=C1OCCN(CC)CC)CCC2=CC=CC=C2
Biological Activity: Etafenone is an antiarrhythmic agent and vasodilator. Etafenone exerts β-adrenergic agonistic effects. Etafenone inhibits the automaticity of sinoatrial nodes, atrioventricular junctions and Purkinje fibers, prolongs action potential duration and refractory period, slows the rising rate of action potentials, and prolongs conduction time. Etafenone enhances collateral circulation after coronary occlusion and suppresses ventricular premature beats. Etafenone delays ischemic myocardial energy imbalance, improves the recovery of high-energy phosphates after ischemia, and reduces myocardial oxygen consumption. Etafenone can be used in research related to ischemic heart disease, arrhythmia and angina pectoris[1][2][3][4].
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Etafenone | Etafenone is an antiarrhythmic agent and vasodilator. Etafenone exerts β-adrenergic agonistic effects. Etafenone inhibits the automaticity of sinoatrial nodes, atrioventricular junctions and Purkinje fibers, prolongs action potential duration and refractory period, slows the rising rate of action potentials, and prolongs conduction time. Etafenone enhances collateral circulation after coronary occlusion and suppresses ventricular premature beats. Etafenone delays ischemic myocardial energy imbalance, improves the recovery of high-energy phosphates after ischemia, and reduces myocardial oxygen consumption. Etafenone can be used in research related to ischemic heart disease, arrhythmia and angina pectoris. | |||||||||||||||||||||
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- [1]. Toda H, et al. Cardiac electrophysiologic effects of etafenone hydrochloride (Dialicor), a new antiarrhythmic agent. Journal of electrocardiology. 1979 Jul;12(3):283-93.
- [2]. Etoh Y, et al. Effects of etafenone on myocardial energy metabolism as studied by an organ redoximeter and biochemical analyses. Japanese journal of pharmacology. 1984 Jul;35(3):229-35.
- [3]. Raberger G, et al. The effects of etafenone on the coronary and femoral circulations before and after adrenergic -blockade in intact dogs. Pharmacology. 1972;7(4):264-70.
- [4]. Kokubun M, et al. Cardiohemodynamic effects of nitroglycerin and several vasodilators. Jpn Heart J. 1974 Mar;15(2):126-44.
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