903639-13-4
903639-13-4
Chemical Structure
ALR-27
- CAS No.: 903639-13-4
- Formula:C19H22O3
- Molecular Weight:298.38
InChIKey: CZAHCAZTHZRDDI-UHFFFAOYSA-N
SMILES: OC1=CC=C(C=C1)CCC2CCC(CO2)C3=CC=C(C=C3)O
Biological Activity: ALR-27 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-27 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM, with no significant direct inhibition of 5-LOX. ALR-27 not only reduces prostaglandin and leukotriene (LT) production in neutrophils but also increases the production of specialized prolytic mediators in specific human macrophage phenotypes[1].
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ALR-27 | ALR-27 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-27 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM, with no significant direct inhibition of 5-LOX. ALR-27 not only reduces prostaglandin and leukotriene (LT) production in neutrophils but also increases the production of specialized prolytic mediators in specific human macrophage phenotypes. | |||||||||||||||||||||
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