904504-22-9
904504-22-9
Chemical Structure
MW01
- CAS No.: 904504-22-9
- Formula:C20H14N2O4
- Molecular Weight:346.34
InChIKey: PBTXUPOGDOSLQB-UHFFFAOYSA-N
SMILES: O=C1C2=C(C3=NC=CC4=C3N1C5=C4C=C(C=C5)O)C=CC(OC)=C2OC
Biological Activity: MW01 is a CLK2/CLK4 inhibitor with IC50 values of 360 nM and 14.1 nM, respectively. MW01 blocks DNA damage-induced IKK/NF-κB signaling and reduces p65 nuclear translocation/phosphorylation as well as radiation-induced IKK-γ phosphorylation/monoubiquitination. MW01 weakly activates γ-H2AX without increasing cleaved caspase-3, and enhances apoptosis by perturbing the NF-κB/p53 axis. MW01 can be used for research on cancer and glioblastoma[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MW01 | MW01 is a CLK2/CLK4 inhibitor with IC50 values of 360 nM and 14.1 nM, respectively. MW01 blocks DNA damage-induced IKK/NF-κB signaling and reduces p65 nuclear translocation/phosphorylation as well as radiation-induced IKK-γ phosphorylation/monoubiquitination. MW01 weakly activates γ-H2AX without increasing cleaved caspase-3, and enhances apoptosis by perturbing the NF-κB/p53 axis. MW01 can be used for research on cancer and glioblastoma. | |||||||||||||||||||||
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