9047-57-8
Chemical Structure
Chondroitinase AC II
- CAS No.: 9047-57-8
- Formula:N/A
- Molecular Weight:N/A
SMILES: [Chondroitinase AC II]
Biological Activity: Chondroitinase AC II is a glycosaminoglycan lyase (EC 4.2.2.5) discovered from Arthrobacter sp. CS01. Chondroitinase AC II exhibits broad substrate specificity toward CS-A, CS-C, and HA. Chondroitinase AC II cleaves the β-1,4-glycosidic bond between D-glucuronic acid and N-acetylgalactosamine through a β-elimination mechanism, producing unsaturated disaccharides and thereby degrading chondroitin sulfate and hyaluronic acid. Chondroitinase AC II activity is enhanced by Mn2+ and inhibited by Zn2+ and Hg2+. Chondroitinase AC II is used for CS oligosaccharide preparation and research related to nerve injury[1][2].
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Chondroitinase AC II | Chondroitinase AC II is a glycosaminoglycan lyase (EC 4.2.2.5) discovered from Arthrobacter sp. CS01. Chondroitinase AC II exhibits broad substrate specificity toward CS-A, CS-C, and HA. Chondroitinase AC II cleaves the β-1,4-glycosidic bond between D-glucuronic acid and N-acetylgalactosamine through a β-elimination mechanism, producing unsaturated disaccharides and thereby degrading chondroitin sulfate and hyaluronic acid. Chondroitinase AC II activity is enhanced by Mn2+ and inhibited by Zn2+ and Hg2+. Chondroitinase AC II is used for CS oligosaccharide preparation and research related to nerve injury. | |||||||||||||||||||||
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Chondroitinase AC | Chondroitinase AC is a hydrolytic enzyme. Chondroitinase AC degrades chondroitin sulfate A and chondroitin sulfate C. Chondroitinase AC inhibits the invasion and proliferation of melanoma cells and endothelial cells, and increases apoptosis. Chondroitinase AC can be used in research on melanoma and other cancers. | |||||||||||||||||||||
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References
- [1]. Fang Y, et al. Expression, Purification and Characterization of Chondroitinase AC II from Marine Bacterium sp. CS01. Marine drugs. 2019 Mar 20;17(3):185.
- [2]. Fang Y, et al. Expression, purification and characterisation of chondroitinase AC II with glyceraldehyde-3-phosphate dehydrogenase tag and chaperone (GroEs-GroEL) from Arthrobacter sp. CS01. International journal of biological macromolecules. 2019 May 15;129:471-476.
