910297-57-3
Chemical Structure
BMS-748730
- CAS No.: 910297-57-3
- Formula:C22H26ClN7O3S
- Molecular Weight:504.00
IUPAC Name: N-(2-chloro-4-hydroxy-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide
InChIKey: YYTXGSVGHHVHNZ-UHFFFAOYSA-N
SMILES: O=C(C1=CN=C(NC2=CC(N3CCN(CC3)CCO)=NC(C)=N2)S1)NC4=C(C)C=C(O)C=C4Cl
Biological Activity: BMS-748730 is an oral tyrosine kinase inhibitor. BMS-748730 inhibits tyrosine kinase activity by competing with the ATP binding site of the tyrosine kinase, which prevents the kinase from phosphorylating the substrate protein, thereby inhibiting signaling pathways associated with cell proliferation and tumor growth. BMS-748730 can be used in the study of certain types of cancer, including chronic myeloid leukemia (CML)[1].
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BMS-748730 | BMS-748730 is an oral tyrosine kinase inhibitor. BMS-748730 inhibits tyrosine kinase activity by competing with the ATP binding site of the tyrosine kinase, which prevents the kinase from phosphorylating the substrate protein, thereby inhibiting signaling pathways associated with cell proliferation and tumor growth. BMS-748730 can be used in the study of certain types of cancer, including chronic myeloid leukemia (CML). | |||||||||||||||||||||
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Keywords
