912921-33-6
912921-33-6
Chemical Structure
GDP-azido-fucose
- CAS 番号: 912921-33-6
- Formula:C16H24N8O15P2
- Molecular Weight:630.35
InChIKey: JSVKWEUGLMCUGG-JGQUBWHWSA-N
SMILES: O=C1C2=C(N([C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(O[C@H]4O[C@H]([C@H]([C@H]([C@@H]4O)O)O)CN=[N+]=[N-])(O)=O)(O)=O)O3)C=N2)NC(N)=N1
Biological Activity: GDP-azido-fucose is a glycoengineering tool. GDP-azido-fucose modifies complex glycans by adding an azido-fucose group. GDP-azido-fucose can install azido-fucose tags on antibody Fc glycans for site-specific payload conjugation, thereby forming antibody-drug conjugates with defined ratios[1][2].
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GDP-azido-fucose | GDP-azido-fucose is a glycoengineering tool. GDP-azido-fucose modifies complex glycans by adding an azido-fucose group. GDP-azido-fucose can install azido-fucose tags on antibody Fc glycans for site-specific payload conjugation, thereby forming antibody-drug conjugates with defined ratios. | |||||||||||||||||||||
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References
- [1]. Shivatare VS, et al. Probing the Internalization and Efficacy of Antibody-Drug Conjugate via Site-Specific Fc-Glycan Labelling of a Homogeneous Antibody Targeting SSEA-4 Bearing Tumors. Israel journal of chemistry. 2023 Oct;63(10-11):e202300042. [Content Brief]
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[2]. Wu, Z. L., et al. (2020). Detecting substrate glycans of fucosyltransferases on glycoproteins with fluorescent fucose. bioRxiv, 2020-01.
Keywords
