91441-23-5
91441-23-5
Chemical Structure
Piroxantrone
Synonym(s): Oxantrazole; NCS 349174
- CAS No.: 91441-23-5
- Formula:C21H25N5O4
- Molecular Weight:411.45
IUPAC Name: 5-((3-aminopropyl)amino)-7,10-dihydroxy-2-(2-((2-hydroxyethyl)amino)ethyl)dibenzo[cd,g]indazol-6(2H)-one
InChIKey: QEWPVAOWLNMLRI-UHFFFAOYSA-N
SMILES: O=C1C2=C3C(N(N=C3C4=C(C=CC(O)=C14)O)CCNCCO)=CC=C2NCCCN
Biological Activity: Piroxantrone (Oxantrazole) is a potent DNA topoisomerase II-targeting anthrapyrazole antitumor agent. Piroxantrone displays cardiotoxicity[1][2].
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Piroxantrone | Piroxantrone (Oxantrazole) is a potent DNA topoisomerase II-targeting anthrapyrazole antitumor agent. Piroxantrone displays cardiotoxicity. | |||||||||||||||||||||
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References
- [1]. Hasinoff BB, et al. The displacement of iron(III) from its complexes with the anticancer drugs piroxantrone and losoxantrone by the hydrolyzed form of the cardioprotective agent dexrazoxane. J Inorg Biochem. 1999 Nov-Dec;77(3-4):257-9. [Content Brief]
- [2]. Frank SK, et al. Preclinical pharmacology of the anthrapyrazole analog oxantrazole (NSC-349174, piroxantrone). Cancer Chemother Pharmacol. 1989;23(4):213-8. [Content Brief]
