91547-59-0
Chemical Structure
1,2-Dideoxy-D-ribofuranose
- CAS No.: 91547-59-0
- Formula:C5H10O3
- Molecular Weight:118.13
IUPAC Name: (2R,3S)-2-(hydroxymethyl)tetrahydrofuran-3-ol
InChIKey: NSMOSDAEGJTOIQ-CRCLSJGQSA-N
SMILES: OC[C@@H]1[C@@H](O)CCO1
Biological Activity: 1,2-Dideoxy-D-ribofuranose is an abasic deoxyribonucleoside (dRH) and a structural analog of the sugar residue at natural apurinic/apyrimidinic sites. When 1,2-Dideoxy-D-ribofuranose is incorporated into the terminal overhang region of the antisense strand of siRNA, it attenuates RNAi-mediated gene silencing. When 1,2-Dideoxy-D-ribofuranose is incorporated as a dimer at the terminus, it enhances the resistance of oligonucleotides to exonuclease degradation. 1,2-Dideoxy-D-ribofuranose can serve as a building block for oligonucleotide synthesis and siRNA modification. 1,2-Dideoxy-D-ribofuranose is also a commonly used building block in the synthesis of carbapenem antibiotics[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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1,2-Dideoxy-D-ribofuranose | 99.99% | 1,2-Dideoxy-D-ribofuranose is an abasic deoxyribonucleoside (dRH) and a structural analog of the sugar residue at natural apurinic/apyrimidinic sites. When 1,2-Dideoxy-D-ribofuranose is incorporated into the terminal overhang region of the antisense strand of siRNA, it attenuates RNAi-mediated gene silencing. When 1,2-Dideoxy-D-ribofuranose is incorporated as a dimer at the terminus, it enhances the resistance of oligonucleotides to exonuclease degradation. 1,2-Dideoxy-D-ribofuranose can serve as a building block for oligonucleotide synthesis and siRNA modification. 1,2-Dideoxy-D-ribofuranose is also a commonly used building block in the synthesis of carbapenem antibiotics. | ||||||||||||||||||||
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