918311-87-2
Chemical Structure
UCL 2077
- CAS No.: 918311-87-2
- Formula:C25H22N2
- Molecular Weight:350.46
IUPAC Name: 1,1,1-triphenyl-N-(pyridin-3-ylmethyl)methanamine
InChIKey: PQFNWDHABGBCHB-UHFFFAOYSA-N
SMILES: C1(CNC(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)=CC=CN=C1
Biological Activity: UCL 2077 is a potassium channel and slow afterhyperpolarization (sAHP) inhibitor. UCL 2077 selectively blocks sAHP channels without affecting L-type Ca2+ currents. UCL 2077 blocks KCNQ1- and KCNQ2-containing K+ channels, decreases erg current amplitude, increases erg deactivation rate. UCL 2077 can be used for the research of hippocampus-dependent memory retrieval deficit and cardiac arrhythmias[1][2][3].
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UCL 2077 | 98.91% | UCL 2077 is a potassium channel and slow afterhyperpolarization (sAHP) inhibitor. UCL 2077 selectively blocks sAHP channels without affecting L-type Ca2+ currents. UCL 2077 blocks KCNQ1- and KCNQ2-containing K+ channels, decreases erg current amplitude, increases erg deactivation rate. UCL 2077 can be used for the research of hippocampus-dependent memory retrieval deficit and cardiac arrhythmias. | ||||||||||||||||||||
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UCL 2077 (Standard) | ≥98% | UCL 2077 (Standard) is the analytical standard of UCL 2077 (HY-108592). This product is intended for research and analytical applications. UCL 2077 is a selective slow-afterhyperpolarization (sAHP) channel blocker (IC50 = 500 nM in hippocampal neurons in culture), having minimal effects on Ca2+ channels, action potentials, input resistance and the medium after hyperpolarization. UCL 2077 is also a subtype-selective blocker of the epilepsy associated KCNQ channels. | ||||||||||||||||||||
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- [1]. Zhang L, et al. The slow afterhyperpolarization: a target of β1-adrenergic signaling in hippocampus-dependent memory retrieval. J Neurosci. 2013;33(11):5006-5016. [Content Brief]
- [2]. Hsu HT, et al. Characterization of Convergent Suppression by UCL-2077 (3-(Triphenylmethylaminomethyl)pyridine), Known to Inhibit Slow Afterhyperpolarization, of erg-Mediated Potassium Currents and Intermediate-Conductance Calcium-Activated Potassium Channels. Int J Mol Sci. 2020;21(4):1441. Published 2020 Feb 20. [Content Brief]
- [3]. Barro-Soria R, et al. KCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channels into two steps. Nat Commun. 2014;5:3750. Published 2014 Apr 28. [Content Brief]
Keywords
