92218-37-6
Chemical Structure
LY164846
- CAS. Nr.: 92218-37-6
- Formula:C18H17N3O4S2
- Molecular Weight:403.48
IUPAC Name: (6R,7R)-7-((R)-2-amino-2-(benzo[b]thiophen-3-yl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
InChIKey: UZIXWKQHCIOPLV-PBFPGSCMSA-N
SMILES: O=C(C(N12)=C(C)CS[C@]2([H])[C@H](NC([C@H](N)C3=CSC4=CC=CC=C43)=O)C1=O)O
Biological Activity: LY164846 is an orally active cephalosporin. LY164846 is highly sensitive to Haemophilus influenzae (including Ampicillin (HY-B0522)-resistant strains) and Moraxella catarrhalis (with MIC90 ≤ 4 μg/mL). LY164846 is generally sensitive to Methicillin (HY-121544)-resistant Staphylococcus aureus and Streptococcus (except Enterococcus) (with MIC90: 0.25 - 8 μg/mL), and moderately sensitive to anaerobic bacteria. LY164846 has MBC/MIC ratio to Haemophilus influenzae of ≤ 2, showing bactericidal activity. LY164846 can be used for research on respiratory and skin infections[1][2].
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LY164846 | LY164846 is an orally active cephalosporin. LY164846 is highly sensitive to Haemophilus influenzae (including Ampicillin (HY-B0522)-resistant strains) and Moraxella catarrhalis (with MIC90 ≤ 4 μg/mL). LY164846 is generally sensitive to Methicillin (HY-121544)-resistant Staphylococcus aureus and Streptococcus (except Enterococcus) (with MIC90: 0.25 - 8 μg/mL), and moderately sensitive to anaerobic bacteria. LY164846 has MBC/MIC ratio to Haemophilus influenzae of ≤ 2, showing bactericidal activity. LY164846 can be used for research on respiratory and skin infections. | |||||||||||||||||||||
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References
- [1]. Lauderdale BL, et al. In vitro activity of an orally administered cephalosporin, LY164846, against potentially pathogenic respiratory and dermal bacterial isolates. Antimicrob Agents Chemother. 1986 Apr;29(4):560-4. [Content Brief]
- [2]. Jones RN, et al. LY164846 in vitro antimicrobial activity testing, including disk diffusion susceptibility tests using 30-microgram disks. Antimicrob Agents Chemother. 1986 Mar;29(3):530-4. [Content Brief]
