925239-03-8
Chemical Structure
JMV 3002
- CAS No.: 925239-03-8
- Formula:C35H34N6O3
- Molecular Weight:586.68
IUPAC Name: (R)-N-(1-(4-(2,4-dimethoxybenzyl)-5-phenethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethyl)picolinamide
InChIKey: UMGBPWZCCHVQAY-WJOKGBTCSA-N
SMILES: O=C(C1=NC=CC=C1)N[C@@H](C2=NN=C(CCC3=CC=CC=C3)N2CC4=CC=C(OC)C=C4OC)CC5=CNC6=C5C=CC=C6
Biological Activity: Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor that stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. JMV3002 is a potent ghrelin receptor antagonist with an IC50 value of 1.1 nM in vitro. 80 μg/kg, JMV3002 inhibits hexarelin-stimulated food intake by as much as 98% in rats. JMV3002 alone does not elicit growth hormone release nor does it inhibit hexarelin-stimulated growth hormone secretion when tested in infant rats at a dose of 160 μg/kg.
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JMV 3002 | Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor that stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. JMV3002 is a potent ghrelin receptor antagonist with an IC50 value of 1.1 nM in vitro. 80 μg/kg, JMV3002 inhibits hexarelin-stimulated food intake by as much as 98% in rats. JMV3002 alone does not elicit growth hormone release nor does it inhibit hexarelin-stimulated growth hormone secretion when tested in infant rats at a dose of 160 μg/kg. | |||||||||||||||||||||
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Keywords
