926623-28-1
Chemical Structure
EC216
Synonym(s): Pte-Cys-ss-DAVLBH
- CAS No.: 926623-28-1
- Formula:C63H75N13O13S2
- Molecular Weight:1286.48
InChIKey: MXAVVXSKSHNXOR-TWDWOHLRSA-N
SMILES: CC[C@@]12[C@@]3([H])[C@@]4(CCN3CC=C2)C5=CC([C@@]6(C7=C(CC[N@@]8C[C@](C[C@](O)(C8)CC)([H])C6)C9=CC=CC=C9N7)C(OC)=O)=C(OC)C=C5N([C@@]4([H])[C@](O)([C@@H]1O)C(NNC(OCCSSC[C@@H](C(O)=O)NC(C%10=CC=C(C=C%10)NCC(N=C%11%12)=CNC%11=NC(N)=NC%12=O)=O)=O)=O)C
Biological Activity: EC216 is a folate receptor (FR) targeted conjugate that competes for binding at the FR site, with a relative binding affinity of 0.046. EC216 is applicable to studies related to folate receptor-targeted delivery and vinca alkaloid cytotoxins[1][2].
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EC216 | EC216 is a folate receptor (FR) targeted conjugate that competes for binding at the FR site, with a relative binding affinity of 0.046. EC216 is applicable to studies related to folate receptor-targeted delivery and vinca alkaloid cytotoxins. | |||||||||||||||||||||
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References
- [1]. Leamon CP, et al. Properties influencing the relative binding affinity of pteroate derivatives and drug conjugates thereof to the folate receptor. Pharmaceutical research. 2009 Jun;26(6):1315-23.
- [2]. Leamon CP, et al.. Folate Receptor Binding Conjugates of Antifolates. US Patent 9,192,682 B2. 2015.
