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Cat. No.: HY-188043

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EC216

Name: EC216
Brand: MedChemExpress
SKU: HY-188043
Availability: PreOrder

(Synonyms: Pte-Cys-ss-DAVLBH)

EC216 is a folate receptor (FR) targeted conjugate that competes for binding at the FR site, with a relative binding affinity of 0.046. EC216 is applicable to studies related to folate receptor-targeted delivery and vinca alkaloid cytotoxins.

For research use only. We do not sell to patients.

CAS No.: 926623-28-1
Formula: C₆₃H₇₅N₁₃O₁₃S₂
Molecular Weight:1286.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

EC216 Chemical Structure

CAS No.: 926623-28-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

All Folate Receptor (FR) Isoforms :

FR-α

In Vitro

EC216 (1 h) exhibits 21.7-fold weaker binding affinity than folic acid for folate receptors on adherent FR-positive human nasopharyngeal KB cells, with a relative affinity of 0.046^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 926623-28-1
Molecular Weight 1286.48
Formula C₆₃H₇₅N₁₃O₁₃S₂
SMILES

CC[C@@]12[C@@]3([H])[C@@]4(CCN3CC=C2)C5=CC([C@@]6(C7=C(CC[N@@]8C[C@](C[C@](O)(C8)CC)([H])C6)C9=CC=CC=C9N7)C(OC)=O)=C(OC)C=C5N([C@@]4([H])[C@](O)([C@@H]1O)C(NNC(OCCSSC[C@@H](C(O)=O)NC(C%10=CC=C(C=C%10)NCC(N=C%11%12)=CNC%11=NC(N)=NC%12=O)=O)=O)=O)C
Synonyms

Pte-Cys-ss-DAVLBH
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Leamon CP, et al. Properties influencing the relative binding affinity of pteroate derivatives and drug conjugates thereof to the folate receptor. Pharmaceutical research. 2009 Jun;26(6):1315-23.

[2]. Leamon CP, et al.. Folate Receptor Binding Conjugates of Antifolates. US Patent 9,192,682 B2. 2015.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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EC216

All Folate Receptor (FR) Isoforms