92676-86-3
Chemical Structure
trans-Cefprozil
- CAS No.: 92676-86-3
- Formula:C18H19N3O5S
- Molecular Weight:389.43
IUPAC Name: (6R,7R)-7-((R)-2-amino-2-(4-hydroxyphenyl)acetamido)-8-oxo-3-((E)-prop-1-en-1-yl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
InChIKey: WDLWHQDACQUCJR-ZAMMOSSLSA-N
SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC([C@H](N)C3=CC=C(O)C=C3)=O)C2=O)(SCC1/C=C/C)[H]
Biological Activity: trans-Cefprozil is a trans-isomer of Cefprozil (HY-B0458A). Cefprozil is a cephalosporin Antibiotic. trans-Cefprozil exhibits antibacterial activity. The antibacterial activity of trans-Cefprozil against Gram-positive bacteria is similar to that of cis-Cefprozil, but its activity against Gram-negative bacteria is lower than that of cis-Cefprozil. trans-Cefprozil can be used for research on Staphylococcus aureus and Escherichia coli infections[1][2][3].
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trans-Cefprozil | trans-Cefprozil is a trans-isomer of Cefprozil (HY-B0458A). Cefprozil is a cephalosporin Antibiotic. trans-Cefprozil exhibits antibacterial activity. The antibacterial activity of trans-Cefprozil against Gram-positive bacteria is similar to that of cis-Cefprozil, but its activity against Gram-negative bacteria is lower than that of cis-Cefprozil. trans-Cefprozil can be used for research on Staphylococcus aureus and Escherichia coli infections. | |||||||||||||||||||||
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References
- [1]. Jang JH, et al. Population Pharmacokinetics of Cis-, Trans-, and Total Cefprozil in Healthy Male Koreans. Pharmaceutics. 2019 Oct 14;11(10):531.
- [2]. Shengxi F, et al. Enzymatic synthesis and in vitro antibacterial activity of trans-cefprozil[J]. 2010.
- [3]. He G, et al. Development and Validation of an HPLC-MS/MS Method for Rapid Simultaneous Determination of Cefprozil Diastereomers in Human Plasma. International journal of analytical chemistry. 2018;2018:6959761.
