927685-43-6
Chemical Structure
Crisdesalazine
Synonym(s): AAD-2004
- CAS No.: 927685-43-6
- Formula:C16H14F3NO3
- Molecular Weight:325.28
IUPAC Name: 2-hydroxy-5-((4-(trifluoromethyl)phenethyl)amino)benzoic acid
InChIKey: UTMVACIBQLDZLP-UHFFFAOYSA-N
SMILES: OC(C1=CC(NCCC2=CC=C(C(F)(F)F)C=C2)=CC=C1O)=O
Biological Activity: Crisdesalazine (AAD-2004) is a microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. Crisdesalazine acts as a potent free radical scavenger that directly neutralizes reactive oxygen species (ROS) including hydrogen peroxide, exerting neuroprotective effects against apoptosis and axonal damage. Crisdesalazine inhibits PGE2 production, mediates inflammatory responses, and promotes the conversion of macrophages from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype. Crisdesalazine is applicable to neuroprotection research in multiple sclerosis and spinal cord injury[1][2].
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Crisdesalazine | 98.92% | Crisdesalazine (AAD-2004) is a microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. Crisdesalazine acts as a potent free radical scavenger that directly neutralizes reactive oxygen species (ROS) including hydrogen peroxide, exerting neuroprotective effects against apoptosis and axonal damage. Crisdesalazine inhibits PGE2 production, mediates inflammatory responses, and promotes the conversion of macrophages from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype. Crisdesalazine is applicable to neuroprotection research in multiple sclerosis and spinal cord injury. | ||||||||||||||||||||
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- [1]. Park SM, et al. Crisdesalazine alleviates inflammation in an experimental autoimmune encephalomyelitis multiple sclerosis mouse model by regulating the immune system. BMC Neurosci. 2025;26(1):1. Published 2025 Jan 3. [Content Brief]
- [2]. Mi X, et al. AAD-2004 through clearing H2O2 reduces astrocyte proliferation and promotes neural regeneration after spinal cord injury. Sci Rep. 2025;16(1):3371. Published 2025 Dec 26. [Content Brief]
Keywords
