928122-40-1
928122-40-1
Chemical Structure
GTx-027
- CAS No.: 928122-40-1
- Formula:C18H14ClN3O3
- Molecular Weight:355.78
InChIKey: IEGVUEFEHAFTNS-SFHVURJKSA-N
SMILES: N#CC(C=C1)=CC=C1OC[C@](C)(O)C(NC2=CC(Cl)=C(C=C2)C#N)=O
Biological Activity: GTx-027 is an orally active and non-steroidal selective androgen receptor modulator (SARM). GTx-027 shows androgen receptor (AR) transactivation effects with the EC50 of 1.8 nM. GTx-027 acts selectively increase muscle weight (anabolic) without affecting secondary sexual organs (androgenic). GTx-027 has the protential for the study of breast cancer and stress urinary incontinence (SUI)[1][2].
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GTx-027 | 99.61% | GTx-027 is an orally active and non-steroidal selective androgen receptor modulator (SARM). GTx-027 shows androgen receptor (AR) transactivation effects with the EC50 of 1.8 nM. GTx-027 acts selectively increase muscle weight (anabolic) without affecting secondary sexual organs (androgenic). GTx-027 has the protential for the study of breast cancer and stress urinary incontinence (SUI). | ||||||||||||||||||||
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References
- [1]. Suriyan Ponnusamy, et al. Tissue Selective Androgen Receptor Modulators (SARMs) Increase Pelvic Floor Muscle Mass in Ovariectomized Mice. J Cell Biochem. 2017 Mar;118(3):640-646. [Content Brief]
- [2]. Narayanan R, et al. Selective androgen receptor modulators (SARMs) negatively regulate triple-negative breast cancer growth and epithelial:mesenchymal stem cell signaling. PLoS One. 2014 Jul 29;9(7):e103202. [Content Brief]
