930470-97-6
Chemical Structure
DG70
Synonym(s): GSK1733953A
- CAS No.: 930470-97-6
- Formula:C21H17ClFNO3
- Molecular Weight:385.82
IUPAC Name: 2-chloro-N-(4',6-dimethoxy-[1,1'-biphenyl]-3-yl)-4-fluorobenzamide
InChIKey: RWSCJEILSRMTEH-UHFFFAOYSA-N
SMILES: O=C(NC1=CC(C2=CC=C(OC)C=C2)=C(OC)C=C1)C3=CC=C(F)C=C3Cl
Biological Activity: DG70 (GSK1733953A), a biphenyl amide, is a respiration inhibitor in Mycobacterium tuberculosis, inhibits MenG activity with an IC50 value of 2.6 ± 0.6 μM. DG70 inhibits the catalytic methylation of Mycobacterium tuberculosis demethylmenaquinone methyltransferase enzymes. DG70 can be used for Tuberculosis (TB) research[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DG70 | 99.70% | DG70 (GSK1733953A), a biphenyl amide, is a respiration inhibitor in Mycobacterium tuberculosis, inhibits MenG activity with an IC50 value of 2.6 ± 0.6 μM. DG70 inhibits the catalytic methylation of Mycobacterium tuberculosis demethylmenaquinone methyltransferase enzymes. DG70 can be used for Tuberculosis (TB) research. | ||||||||||||||||||||
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- [1]. Pujari V, et al. Mycobacterial MenG: Partial Purification, Characterization, and Inhibition. ACS Infect Dis. 2022 Dec 9;8(12):2430-2440. [Content Brief]
- [2]. Adewumi AT, et al. Thompson loop: opportunities for antitubercular drug design by targeting the weak spot in demethylmenaquinone methyltransferase protein. RSC Adv. 2020 Jun 19;10(39):23466-23483. [Content Brief]
- [3]. Sukheja P, et al. A Novel Small-Molecule Inhibitor of the Mycobacterium tuberculosis Demethylmenaquinone Methyltransferase MenG Is Bactericidal to Both Growing and Nutritionally Deprived Persister Cells. mBio. 2017 Feb 14;8(1):e02022-16. [Content Brief]
Keywords
