94345-47-8
94345-47-8
Chemical Structure
Heptamidine
Synonym(s): SBi4211
- CAS No.: 94345-47-8
- Formula:C21H28N4O2
- Molecular Weight:368.47
IUPAC Name: 4,4'-(heptane-1,7-diylbis(oxy))dibenzimidamide
InChIKey: IUJKKCRARYRWFG-UHFFFAOYSA-N
SMILES: N=C(C1=CC=C(OCCCCCCCOC2=CC=C(C(N)=N)C=C2)C=C1)N
Biological Activity: Heptamidine (SBi4211) is a potent Pentamidine-related inhibitor of the calcium-binding protein S100B (Kd=6.9 μM), selectively kills melanoma cells with S100B over those without S100B[1]. Heptamidine is a useful tool for the investigation of Myotonic dystrophy (DM)[2].
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Heptamidine | Heptamidine (SBi4211) is a potent Pentamidine-related inhibitor of the calcium-binding protein S100B (Kd=6.9 μM), selectively kills melanoma cells with S100B over those without S100B. Heptamidine is a useful tool for the investigation of Myotonic dystrophy (DM). | |||||||||||||||||||||
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References
- [1]. McKnight LE, et al. Structure-Based Discovery of a Novel Pentamidine-Related Inhibitor of the Calcium-Binding Protein S100B. ACS Med Chem Lett. 2012 Dec 13;3(12):975-979. Epub 2012 Sep 25. [Content Brief]
- [2]. Coonrod LA, et al. Reducing levels of toxic RNA with small molecules.ACS Chem Biol. 2013 Nov 15;8(11):2528-37. [Content Brief]
Keywords
