944278-62-0
Chemical Structure
AZD2836
Synonym(s): A-831
- CAS No.: 944278-62-0
- Formula:C24H20N6O2
- Molecular Weight:424.45
IUPAC Name: N-(4-(1H-1,2,4-triazol-1-yl)phenyl)-6-(3,4-dimethoxyphenyl)quinazolin-4-amine
InChIKey: UPPWMBQIDFTBEQ-UHFFFAOYSA-N
SMILES: COC(C=CC(C(C=C12)=CC=C1N=CN=C2NC(C=C3)=CC=C3N4N=CN=C4)=C5)=C5OC
Biological Activity: AZD2836 (A-831) is a 4-aminopyrazolone compound with anti-HCV activity. AZD2836 inhibits the activity of the host cell kinase PI4KIIIα, causing metabolic disorder of the cell membrane component PI4P that is necessary for viral replication. In the HCV subgenomic replicon cell model, the EC50 values of AZD2836 for genotype 1b (Con1 strain) and genotype 1a (Lemon strain) are 270 nM and 550 nM, respectively[1][2].
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AZD2836 | AZD2836 (A-831) is a 4-aminopyrazolone compound with anti-HCV activity. AZD2836 inhibits the activity of the host cell kinase PI4KIIIα, causing metabolic disorder of the cell membrane component PI4P that is necessary for viral replication. In the HCV subgenomic replicon cell model, the EC50 values of AZD2836 for genotype 1b (Con1 strain) and genotype 1a (Lemon strain) are 270 nM and 550 nM, respectively. | |||||||||||||||||||||
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- [1]. Bianco A, et al. Metabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity. PLoS pathogens. 2012 Mar 8;8(3):e1002576.
- [2]. Schmitz U, Tan SL. NS5A-from obscurity to new target for HCV therapy. Recent patents on anti-infective drug discovery. 2008 Jun 1;3(2):77-92.
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