949575-20-6
Chemical Structure
MIP-1072
- CAS No.: 949575-20-6
- Formula:C19H26IN3O7
- Molecular Weight:535.33
IUPAC Name: (((S)-1-carboxy-5-((4-iodobenzyl)amino)pentyl)carbamoyl)-L-glutamic acid
InChIKey: OXUUJYOSVPMNKP-GJZGRUSLSA-N
SMILES: OC(CC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCCCNCC1=CC=C(C=C1)I)=O)=O
Biological Activity: MIP-1072 is a competitive prostate-specific membrane antigen (PSMA) inhibitor with a Ki value of 4.6 nM. MIP-1072 specifically binds to PSMA and is internalized into PSMA-expressing prostate cancer cells. MIP-1072 accumulates in PSMA-expressing prostate cancer xenografts. MIP-1072 specifically blocks the uptake of 68Ga-NOTA-GUL by PSMA-positive prostate cancer xenografts. When radiolabeled with 123I, MIP-1072 functions as a SPECT/CT molecular imaging agent. MIP-1072 can be used in prostate cancer-related research[1][2][3].
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MIP-1072 | MIP-1072 is a competitive prostate-specific membrane antigen (PSMA) inhibitor with a Ki value of 4.6 nM. MIP-1072 specifically binds to PSMA and is internalized into PSMA-expressing prostate cancer cells. MIP-1072 accumulates in PSMA-expressing prostate cancer xenografts. MIP-1072 specifically blocks the uptake of 68Ga-NOTA-GUL by PSMA-positive prostate cancer xenografts. When radiolabeled with 123I, MIP-1072 functions as a SPECT/CT molecular imaging agent. MIP-1072 can be used in prostate cancer-related research. | |||||||||||||||||||||
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- [1]. Hillier SM, et al. Preclinical evaluation of novel glutamate-urea-lysine analogues that target prostate-specific membrane antigen as molecular imaging pharmaceuticals for prostate cancer. Cancer research. 2009 Sep 01;69(17):6932-40. [Content Brief]
- [2]. Hillier SM, et al. 123I-MIP-1072, a small-molecule inhibitor of prostate-specific membrane antigen, is effective at monitoring tumor response to taxane therapy. J Nucl Med. 2011 Jul;52(7):1087-93. [Content Brief]
- [3]. Moon SH, et al. Development of a Ga-68 labeled PET tracer with short linker for prostate-specific membrane antigen (PSMA) targeting. Bioorganic & medicinal chemistry. 2018 May 15;26(9):2501-2507. [Content Brief]
Keywords
