95722-07-9
Chemical Structure
(R)-Cicaprost
Synonym(s): (R)-ZK 96480
- CAS No.: 95722-07-9
- Formula:C22H30O5
- Molecular Weight:374.48
IUPAC Name: 2-(2-((3aS,4S,5R,6aS,E)-5-hydroxy-4-((3S,4R)-3-hydroxy-4-methylnona-1,6-diyn-1-yl)hexahydropentalen-2(1H)-ylidene)ethoxy)acetic acid
InChIKey: ARUGKOZUKWAXDS-PVQFIELRSA-N
SMILES: C(#C[C@H]([C@@H](CC#CCC)C)O)[C@@H]1[C@@]2([C@@](C/C(=C\COCC(O)=O)/C2)(C[C@H]1O)[H])[H]
Biological Activity: (R)-Cicaprost ((R)-ZK 96480) is an isomer of Cicaprost (HY-19583). Cicaprost is an orally active prostacyclin analog. Cicaprost inhibits platelet aggregation and release, and induces vasodilation. Cicaprost can be used in research related to breast cancer and pulmonary arterial hypertension[1][2][3].
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(R)-Cicaprost | (R)-Cicaprost ((R)-ZK 96480) is an isomer of Cicaprost (HY-19583). Cicaprost is an orally active prostacyclin analog. Cicaprost inhibits platelet aggregation and release, and induces vasodilation. Cicaprost can be used in research related to breast cancer and pulmonary arterial hypertension. | |||||||||||||||||||||
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References
- [1]. Schneider MR, et al. Antimetastatic action of the prostacyclin analogue cicaprost in experimental mammary tumors. Breast cancer research and treatment. 1996;38(1):133-41.
- [2]. Belch JJ, et al. Cicaprost, an orally active prostacyclin analogue: its effects on platelet aggregation and skin blood flow in normal volunteers. British journal of clinical pharmacology. 1993 Jun;35(6):643-7.
- [3]. Sobolewski A, et al. Mechanism of cicaprost-induced desensitization in rat pulmonary artery smooth muscle cells involves a PKA-mediated inhibition of adenylyl cyclase. American journal of physiology. Lung cellular and molecular physiology. 2004 Aug;287(2):L352-9.
