959772-67-9
Chemical Structure
Berkeleyacetal C
- CAS No.: 959772-67-9
- Formula:C24H26O8
- Molecular Weight:442.46
IUPAC Name: (2S,3aR,3a1S,5aR,6aR,7R,13aS,13bR)-2,5a,11,11,13a-pentamethyl-3a1,5a,6,6a,13a,13b-hexahydro-9H-spiro[furo[4,3,2-ij]pyrano[4',3':4,5]cyclohepta[1,2-f]isochromene-7,2'-oxirane]-1,5,9,13(2H,3aH,11H)-tetraone
InChIKey: PCBBMDQLBUYDDZ-MBEBNAQTSA-N
SMILES: C[C@@]12[C@](C[C@@]3([C@]4([H])[C@@]2([H])C([C@@H](O[C@]4([H])OC3=O)C)=O)C)([H])[C@]5(CO5)C(C(C(C)(O6)C)=CC1=O)=CC6=O
Biological Activity: keleyacetal C, a meroterpenoid compound with anti-inflammatory effects via inhibiting NF-κB, ERK1/2 and IRF3 signaling pathways. Berkeleyacetal C significantly inhibits the expression of iNOS and the following NO production by macrophages. Berkeleyacetal C inhibits expression and secretion of key pro-inflammatory factors and chemokines (TNF-α, IL-6, IL-1β, MIP-1α, and MCP-1). Berkeleyacetal C also inhibits activation of neutrophils and reactive oxygen species (ROS) production. Berkeleyacetal C can be used for the study of inflammatory disorders[1].
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Berkeleyacetal C | keleyacetal C, a meroterpenoid compound with anti-inflammatory effects via inhibiting NF-κB, ERK1/2 and IRF3 signaling pathways. Berkeleyacetal C significantly inhibits the expression of iNOS and the following NO production by macrophages. Berkeleyacetal C inhibits expression and secretion of key pro-inflammatory factors and chemokines (TNF-α, IL-6, IL-1β, MIP-1α, and MCP-1). Berkeleyacetal C also inhibits activation of neutrophils and reactive oxygen species (ROS) production. Berkeleyacetal C can be used for the study of inflammatory disorders. | |||||||||||||||||||||
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Keywords
