96-99-1
Chemical Structure
4-Chloro-3-nitrobenzoic acid
- CAS. Nr.: 96-99-1
- Formula:C7H4ClNO4
- Molecular Weight:201.56
IUPAC Name: 4-chloro-3-nitrobenzoic acid
InChIKey: DFXQXFGFOLXAPO-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=C(Cl)C([N+]([O-])=O)=C1
Biological Activity: 4-Chloro-3-nitrobenzoic acid is a benzoic acid derivative and an important intermediate for the synthesis of anticancer agents. 4-Chloro-3-nitrobenzoic acid shows low cytotoxicity against HepG2, A549 and HeLa cancer cells in vitro (>10,000 μM). 4-Chloro-3-nitrobenzoic acid can block thymidine uptake and inhibit lymphocyte growth. 4-Chloro-3-nitrobenzoic acid serves as a ligand for Cu (II) complexes and is used in the preparation of 10H-pyrazino[2,3-b][1,4]benzothiazine derivatives[1][2][3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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4-Chloro-3-nitrobenzoic acid | 99.39% | 4-Chloro-3-nitrobenzoic acid is a benzoic acid derivative and an important intermediate for the synthesis of anticancer agents. 4-Chloro-3-nitrobenzoic acid shows low cytotoxicity against HepG2, A549 and HeLa cancer cells in vitro (>10,000 μM). 4-Chloro-3-nitrobenzoic acid can block thymidine uptake and inhibit lymphocyte growth. 4-Chloro-3-nitrobenzoic acid serves as a ligand for Cu (II) complexes and is used in the preparation of 10H-pyrazino[2,3-b][1,4]benzothiazine derivatives. | ||||||||||||||||||||
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References
- [1]. Kinchington D, et al. T cell costimulation by derivatives of benzoic acid[J]. Antiviral Chemistry and Chemotherapy, 1997, 8(2): 121-130.
- [2]. Kaneko T, et al. Inhibitors of adhesion molecules expression; the synthesis and pharmacological properties of 10H-pyrazino [2, 3-b][1, 4] benzothiazine derivatives[J]. Chemical and pharmaceutical bulletin, 2002, 50(7): 922-929.
- [3]. Zeng ZF, et al. Synthesis, Characterization, DNA/HSA Interactions, and Anticancer Activity of Two Novel Copper(II) Complexes with 4-Chloro-3-Nitrobenzoic Acid Ligand. Molecules. 2021;26(13):4028. Published 2021 Jul 1. [Content Brief]
