961-45-5
Chemical Structure
8-Phenyltheophylline
- CAS No.: 961-45-5
- Formula:C13H12N4O2
- Molecular Weight:256.26
IUPAC Name: 1,3-dimethyl-8-phenyl-3,9-dihydro-1H-purine-2,6-dione
InChIKey: PJFMAVHETLRJHJ-UHFFFAOYSA-N
SMILES: O=C(N1C)N(C)C2=C(N=C(C3=CC=CC=C3)N2)C1=O
Biological Activity: 8-Phenyltheophylline is an adenosine receptor (adenosine receptor) antagonist. 8-Phenyltheophylline blocks adenosine-stimulated cAMP accumulation, inhibits tissue-selective cAMP hydrolysis, and antagonizes the inhibitory effects of adenosine. 8-Phenyltheophylline enhances apomorphine-induced rotational behavior in lesioned rats, reverses the analgesic effect of morphine in the rat hot plate test, and slightly enhances contractile responses of the atrium and ileum. 8-Phenyltheophylline can be used in studies related to unilateral nigrostriatal pathway injury[1].
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8-Phenyltheophylline | 8-Phenyltheophylline is an adenosine receptor (adenosine receptor) antagonist. 8-Phenyltheophylline blocks adenosine-stimulated cAMP accumulation, inhibits tissue-selective cAMP hydrolysis, and antagonizes the inhibitory effects of adenosine. 8-Phenyltheophylline enhances apomorphine-induced rotational behavior in lesioned rats, reverses the analgesic effect of morphine in the rat hot plate test, and slightly enhances contractile responses of the atrium and ileum. 8-Phenyltheophylline can be used in studies related to unilateral nigrostriatal pathway injury. | |||||||||||||||||||||
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