99570-57-7
Chemical Structure
U 68215
- CAS No.: 99570-57-7
- Formula:C24H34O5
- Molecular Weight:402.53
IUPAC Name: 2-(((1R,2R,3aS,9aS)-1-((R)-3-cyclohexyl-3-hydroxypropyl)-2-hydroxy-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl)oxy)acetic acid
InChIKey: UVTYVOJZXZTZHN-PLJZGSKRSA-N
SMILES: C(C[C@@H](O)C1CCCCC1)[C@@H]2[C@@]3([C@@](CC=4C(C3)=CC=CC4OCC(O)=O)(C[C@H]2O)[H])[H]
Biological Activity: U 68215 is an orally active benzindene prostacyclin (PGI2) analog. U 68215 exhibits potent anti-gastric ulcer and gastric emptying inhibitory effects without inducing side effects such as diarrhea. U 68215 can be used in studies on peptic ulcer treatment and gastrointestinal cytoprotection[1][2].
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U 68215 | U 68215 is an orally active benzindene prostacyclin (PGI2) analog. U 68215 exhibits potent anti-gastric ulcer and gastric emptying inhibitory effects without inducing side effects such as diarrhea. U 68215 can be used in studies on peptic ulcer treatment and gastrointestinal cytoprotection. | |||||||||||||||||||||
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References
- [1]. Aristoff PA, et al. Total synthesis of a novel antiulcer agent via a modification of the intramolecular Wadsworth-Emmons-Wittig reaction. Journal of the American Chemical Society. 1985 Dec;107(26):7967-74.
- [2]. Shea-Donohue T, et al. Effects of a prostacyclin analog, U-68,215, on gastric acid secretion, gastric emptying and systemic blood pressure in primates. The Journal of pharmacology and experimental therapeutics. 1992 Mar;260(3):1023-7.
