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Cat. No.: HY-187559

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U 68215

U 68215 is an orally active benzindene prostacyclin (PGI2) analog. U 68215 exhibits potent anti-gastric ulcer and gastric emptying inhibitory effects without inducing side effects such as diarrhea. U 68215 can be used in studies on peptic ulcer treatment and gastrointestinal cytoprotection.

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CAS No.: 99570-57-7
Formule: C₂₄H₃₄O₅
Masse moléculaire:402.53

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

U 68215 Chemical Structure

CAS No.: 99570-57-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

In Vivo

U 68215 (p.o.) exhibits potent cytoprotective and gastric antisecretory activities in rat models, and acts as an effective anti-ulcer agent without causing side effects such as diarrhea^[1].
U 68215 (25-100 μg/kg; i.g.; single dose; treatment duration 60 min) significantly inhibits gastric acid secretion, suppresses gastric emptying and reduces systemic blood pressure in primate animal models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Primates were subcutaneously injected with 1 mg/kg histalog 30 minutes prior to administration to stimulate gastric acid secretion^[2]
Dosage:

25, 50, 100 μg/kg
Administration:

i.g., single dose, gastric function was determined for 60 minutes after a 30-minute equilibration period
Result:

Produced a 94% maximum suppression of acid output from 60 to 90 min after the 100 μg/kg dose.
Significantly inhibited gastric emptying at all tested doses.
Induced no diarrhea in response to any dose.
Significantly inhibited systolic blood pressure only after the 100 μg/kg dose, whereas diastolic blood pressure was reduced significantly by both 50 and 100 μg/kg doses.

Chemical Information

CAS No. 99570-57-7
Masse moléculaire 402.53
Formule C₂₄H₃₄O₅
SMILES

C(C[C@@H](O)C1CCCCC1)[C@@H]2[C@@]3([C@@](CC=4C(C3)=CC=CC4OCC(O)=O)(C[C@H]2O)[H])[H]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Aristoff PA, et al. Total synthesis of a novel antiulcer agent via a modification of the intramolecular Wadsworth-Emmons-Wittig reaction. Journal of the American Chemical Society. 1985 Dec;107(26):7967-74.

[2]. Shea-Donohue T, et al. Effects of a prostacyclin analog, U-68,215, on gastric acid secretion, gastric emptying and systemic blood pressure in primates. The Journal of pharmacology and experimental therapeutics. 1992 Mar;260(3):1023-7.

Calculators

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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