99593-25-6
99593-25-6
Chemical Structure
Rilmazafone
- CAS No.: 99593-25-6
- Formula:C21H20Cl2N6O3
- Molecular Weight:475.33
IUPAC Name: 5-((2-aminoacetamido)methyl)-1-(4-chloro-2-(2-chlorobenzoyl)phenyl)-N,N-dimethyl-1H-1,2,4-triazole-3-carboxamide
InChIKey: KYHFRCPLIGODFH-UHFFFAOYSA-N
SMILES: NCC(NCC1=NC(C(N(C)C)=O)=NN1C2=C(C=C(Cl)C=C2)C(C3=C(C=CC=C3)Cl)=O)=O
Biological Activity: Rilmazafone (450191S) is an orally active sleep inducer. Rilmazafone targets cytochrome P-450b and cytochrome P-450e. Rilmazafone induces hepatic drug-metabolizing enzyme activity in rats, mice and dogs. Rilmazafone is applicable for insomnia-related research[1][2].
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Rilmazafone | Rilmazafone (450191S) is an orally active sleep inducer. Rilmazafone targets cytochrome P-450b and cytochrome P-450e. Rilmazafone induces hepatic drug-metabolizing enzyme activity in rats, mice and dogs. Rilmazafone is applicable for insomnia-related research. | |||||||||||||||||||||
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References
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[1]. Takashi MATSUBARA 1, et al. Effect of Change of Hepatic Drug-Metabolizing Activity on Plasma Concentrations of Major Metabolites of the New Sleep Inducer 450191-S, a 1H-1,2,4-Triazolyl Benzophenone Derivative. Japanese Journal of Pharmacology. 1987;4(44).
- [2]. Tsutsui R, et al. Hypnotic and sleep quality-enhancing properties of kavain in sleep-disturbed rats. J Pharmacol Sci. 2009;111(3):293-298. [Content Brief]
