99660-94-3
Chemical Structure
1,2,3-Trieicosapentaenoyl glycerol
Synonym(s): EPA-TG; Glycerol trieicosapentaenoate; TG(20:5/20:5/20:5)
- CAS No.: 99660-94-3
- Formula:C63H92O6
- Molecular Weight:945.40
InChIKey: SHYCFZYQNVKAAU-UZBXBHHFSA-N
SMILES: C(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CC)=O)(COC(CCC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CC)=O)COC(CCC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CC)=O
Biological Activity: 1,2,3-Trieicosapentaenoyl glycerol (EPA-TG) is a glycerol ester that can be obtained by the reaction of polyunsaturated fatty acids or lower alkyl esters with glycerol catalyzed by alkoxide ions[1]. After two intravenous injections of the EPA-TG emulsion into rabbits, the EPA content in plasma and platelet phospholipids increased markedly[2]. In another study, by administering the EPA-TG emulsion, the production of leukotriene B4 by polymorphonuclear leukocytes in rabbits was reduced by 40%[3].
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1,2,3-Trieicosapentaenoyl glycerol | 99.9% | 1,2,3-Trieicosapentaenoyl glycerol (EPA-TG) is a glycerol ester that can be obtained by the reaction of polyunsaturated fatty acids or lower alkyl esters with glycerol catalyzed by alkoxide ions. After two intravenous injections of the EPA-TG emulsion into rabbits, the EPA content in plasma and platelet phospholipids increased markedly. In another study, by administering the EPA-TG emulsion, the production of leukotriene B4 by polymorphonuclear leukocytes in rabbits was reduced by 40%. | ||||||||||||||||||||
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- [1]. Process for preparing triglycerides containing polyunsaturated fatty acid moieties. U5149851.
- [2]. Urakaze M, Hamazaki T, Soda Y, et al. Infusion of emulsified trieicosapentaenoyl-glycerol into rabbits--the effects on platelet aggregation, polymorphonuclear leukocyte adhesion, and fatty acid composition in plasma and platelet phospholipids. Thromb Res. 1986;44(5):673-682. [Content Brief]
- [3]. Hamazaki T. Intravenous infusion of n-3 polyunsaturated fatty acids. Proc Soc Exp Biol Med. 1992;200(2):171-173. [Content Brief]
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