AGN-2979
AGN‑2979 (SC 48274; BTG 1501) is an orally active and selective tryptophan hydroxylase inhibitor with antidepressant-like and anxiolytic-like activities. AGN‑2979 inhibits stress-induced activation of tryptophan hydroxylase, thereby limiting the biosynthesis of 5-hydroxytryptamine in the brain. AGN-2979 possesses non-sedative anxiolytic and cognitive-enhancing properties. AGN-2979 is applicable to research related to depression and generalized anxiety disorder.
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- CAS. Nr.: 53873-21-5
- Formel: C19H28N2O3
- Molecular Weight:332.44
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vivo
AGN‑2979 induces transient behavioral changes characterized by sedation and hypoactivity in both stressed and control Wistar rats, and these abnormal behaviors disappear after 3 weeks of administration[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 53873-21-5
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Molecular Weight 332.44
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Formel C19H28N2O3
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SMILES
O=C1NC(C(CCCN(C)C)(C(C)(C1)C)C2=CC(OC)=CC=C2)=O
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Synonyms
SC 48274; BTG 1501
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Gittos MW, et al. Antidepressant-like action of AGN 2979, a tryptophan hydroxylase activation inhibitor, in a chronic mild stress model of depression in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2001 Oct;11(5):351-7. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
AGN-2979 Related Classifications
HY-19046A Related Classifications
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Keywords
- AGN-2979
- 53873-21-5
- SC 48274
- BTG 1501
- AGN2979
- AGN 2979
- SC48274
- SC-48274
- BTG1501
- BTG 1501
- BTG-1501
- Tryptophan Hydroxylase
- generalized anxiety disorder
- antidepressant-like activity
- monoaminergic neurotransmission reuptake
- muscarinic ligands
- non-sedating anxiolytic
- neuronal K+ channel
- depression
- tryptophan hydroxylase
- cognitive enhancing properties
- Inhibitor
- inhibitor
- inhibit