AL-6556

AL-6556 (0.1 nM-100 μM) shows highest affinity for human platelet DP receptors with a K_i of 3200 nM, 21-37-fold selectivity over EP3, FP, IP, and TP prostanoid receptors, and moderate affinity for EP1 and EP4 receptors^[1].
AL-6556 (10 μM) weakly interacts with most nonprostanoid receptors, with the strongest inhibition (47.5%) observed at the platelet activating factor receptor^[1].
AL-6556 (0.1 nM-100 μM; 15 min) acts as a full agonist at embryonic bovine tracheal fibroblast DP receptors, stimulating cAMP production with an EC₅₀ of 799 nM and 93% maximum efficacy relative to PGD₂^[1].
AL-6556 (0.1 nM-100 μM; 15 min) acts as a partial agonist at human nonpigmented epithelial cell EP2 receptors, stimulating cAMP production with an EC₅₀ of 1180 nM and 35% maximum efficacy relative to PGE₂, with no agonist activity at EP4, IP, or FP receptors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.