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Art. -Nr.: HY-P992181

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AMG-329

(Synonyms: MEDI1116; VIB-1116; HZN-1116)

AMG-329 (MEDI1116) is a human immunoglobulin G1λ monoclonal antibody targeting FLT3L. AMG-329 selectively binds to FLT3L, blocks FLT3L-FLT3 interaction, neutralizes soluble and cell-bound human FLT3L activity. AMG-329 reduces circulating relative proportions of plasmacytoid dendritic cells, conventional dendritic cells, and classical monocytes. AMG-329 does not induce antibody dependent cellular cytotoxicity. AMG-329 can be used for the research of sjögren’s disease.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

AMG-329 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- In Vitro
- In Vivo
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Anwendung
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Isotype

Human IgG1 lambda

Recommend Isotype Controls

Human IgG1 lambda1, Isotype Control

Species Reactivity

Human

In Vitro

AMG-329 neutralizes soluble human FLT3L in RS4;11 cells, with no activity against mouse or rat FLT3L^[1].
AMG-329 neutralizes cell-bound human FLT3L in CD4⁺ T cell-RS4^[1].
AMG-329 (10^-3-10² μg/mL; 6 h) does not induce ADCC in IL-7-treated human CD4⁺ T cells co-cultured with allogeneic PBMCs^[1].
AMG-329 (0.001-100 μg/mL; overnight) does not bind purified human C1q^[1].
AMG-329 is specific to FLT3L and does not interact with other class III tyrosine kinase receptor ligands including SCF, M-CSF, and PDGF^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AMG-329 (5-100 mg/kg (s.c.) or 100 mg/kg (i.v.); once weekly; 5 doses) induces non-dose-dependent, reversible reductions in relative proportions of peripheral blood pDCs, cDC1s, cDC2s, and classical monocytes in healthy cynomolgus monkeys, while preserving T-cell-dependent antibody responses^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Cynomolgus monkeys (male and female)^[1]
Dosage:

5; 30; 100 mg/kg
Administration:

s.c.; i.v. (100 mg/kg); once weekly; 5 doses
Result:

Induced significant decreases in plasmacytoid dendritic cells (pDCs) relative to baseline vs control starting on day 8 of the 5-week study, with maximal decreases between days 25 and 81 of recovery.
Induced significant decreases in conventional dendritic cell 1 (cDC1) relative to baseline vs control in the 5-week study, with depletion maintained through day 109 of recovery.
Induced significant decreases in conventional dendritic cell 2 (cDC2) relative to baseline vs control in the 5-week study, maintained through day 81 of recovery.
Induced significant decreases in classical monocytes relative to baseline vs control on day 29 of the 5-week study.
Caused all affected cell subsets to generally return to baseline levels by the end of the recovery phase for both studies.
Showed no significant changes in nonclassical monocytes, intermediate monocytes, or B cells.
Resulted in no differences in anti-keyhole limpet hemocyanin (KLH) IgM or IgG titers between treated and control animals.

Gene ID

2323 [NCBI]

Accession

P49771

Target

FLT3L

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Product Image

Anwendung

ELISA, FACS, Functional assay

Chemical Information

Synonyms

MEDI1116; VIB-1116; HZN-1116
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. Lau-Kilby A, et al. Development and preclinical characterization of AMG 329: a human antibody neutralizing FLT3 ligand. MAbs. 2025;17(1):2527677. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- In Vitro
- In Vivo
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Anwendung
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
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Reinheit:
Menge:

AMG-329

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

PBS Buffer (1×)