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Art. -Nr.: HY-149950

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Anticancer agent 106

Anticancer agent 106 (compound 10ic) is an anticancer agent that induces apoptosis in B16-F10 melanoma cells. Anticancer agent 106 also potently inhibits metastatic nodules in a mouse model of lung metastatic melanoma. Anticancer agent 106 can be used in the study of cancer, especially lung metastatic melanoma.

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CAS. Nr.: 3009090-13-2
Formel: C₂₆H₂₅N₃O₄S
Molecular Weight:475.56

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

Anticancer agent 106 Chemical Structure

CAS. Nr.: 3009090-13-2

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
4T1	IC₅₀	6.5 μM Compound: 10ic	Cytotoxicity against mouse 4T1 cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis Cytotoxicity against mouse 4T1 cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis	[PMID: 37084598]
B16-F10	IC₅₀	4.8 μM Compound: 10ic	Cytotoxicity against mouse B16-F10 cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis Cytotoxicity against mouse B16-F10 cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis	[PMID: 37084598]
CT26	IC₅₀	7.4 μM Compound: 10ic	Cytotoxicity against mouse CT26 cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis Cytotoxicity against mouse CT26 cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis	[PMID: 37084598]
MEF	IC₅₀	>100 μM Compound: 10ic	Cytotoxicity against NF2-deficient mouse MEF cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis Cytotoxicity against NF2-deficient mouse MEF cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis	[PMID: 37084598]

In Vitro

Anticancer agent 106 (compound 10ic; 0.28-55 μM; 24 h) reduces the viability of B16-F10 melanoma cells in a dose-dependent manner, with an IC₅₀ value of 4.8 μM^[1].
Anticancer agent 106 (5-20 μM; 48 h) induces apoptosis of B16-F10 melanoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

B16-F10 melanoma cells
Concentration:

0.28-55 μM
Incubation Time:

24 h
Result:

Inhibited B16-F10 melanoma cells in a dose-dependent manner (IC₅₀ = 4.8 μM).

Apoptosis Analysis^[1]

Cell Line:

B16-F10 melanoma cells
Concentration:

5-20 μM
Incubation Time:

48 h
Result:

Induced cell apoptosis.

In Vivo

Anticancer agent 106 (9-9.5 mg/kg; i.p.; every 3rd d for 22 d) inhibits the metastatic nodules in pulmonary metastatic melanoma mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

B16-F10 melanoma-bearing C57BL/6 mice (pulmonary metastatic melanoma model)^[1].
Dosage:

9-9.5 mg/kg
Administration:

Intraperitoneal administration; every 3rd d for 22 d.
Result:

Inhibited the lung metastases.

Chemical Information

CAS. Nr. 3009090-13-2
Molecular Weight 475.56
Formel C₂₆H₂₅N₃O₄S
SMILES

N#CC1=C(N)N(C2=C(C(OCC)=O)C(CCCCC3)=C3S2)/C(C1=O)=C/C(C4=CC=C(C)C=C4)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Anna Rogova, et al. Synthesis of thieno[3,2-e]pyrrolo[1,2-a]pyrimidine derivatives and their precursors containing 2-aminothiophenes fragments as anticancer agents for therapy of pulmonary metastatic melanoma. Eur J Med Chem. 2023, 254: 115325.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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