ATZ-1993
ATZ-1993 is an orally active, nonpeptide endothelin receptor subtype Aand endothelin receptor subtype B antagonist with pKi values of 8.69, 7.20, respectively. ATZ-1993 has the potential for the research of intimal hyperplasia after balloon denudation of the carotid artery.
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- CAS. Nr.: 219705-77-8
- Formel: C28H28N4O4
- Molecular Weight:484.55
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
ETA 8.69 (pKi) |
ETB 7.20 (pKi) |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Japanese White male rabbits[1]
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Dosage:30 mg/kg
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Administration:Drinking water, daily for 1 weeks
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Result:Inhibited the intimal hyperplasia with the inhibition rate approximately 77%, increased in intima:media ratio and DNA content.
Chemical Information
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CAS. Nr. 219705-77-8
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Molecular Weight 484.55
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Formel C28H28N4O4
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SMILES
O=C(C1=NN(C(C2=CC=CC(OCC)=C2)CC)C3=C1CCC4=CC(OCC5=CN=CN=C5)=CC=C43)O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
ATZ-1993 Related Classifications
HY-122237 Related Classifications
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