Bcl-2-IN-4
Bcl-2-IN-4 is a potent, orally active and selective Bcl-2 inhibitor with an IC50 of 1.5 nM. Bcl-2-IN-4 displays >200-fold selectivity over Bcl-xL (IC50 of 411 nM). Bcl-2-IN-4 inhibits RS4; 11 cell proliferation with an IC50 of 2.7 nM (WO2021180040A1; compound 2).
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- CAS. Nr.: 2703134-40-9
- Formel: C46H50ClN9O7S
- Molecular Weight:908.46
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
Bcl-2 1.5 nM (IC50) |
Bcl-xL 411 nM (IC50) |
Chemical Information
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CAS. Nr. 2703134-40-9
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Molecular Weight 908.46
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Formel C46H50ClN9O7S
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SMILES
O=C(NS(=O)(C1=C2C(N=CN2)=C(NCC3CCOCC3)C([N+]([O-])=O)=C1)=O)C4=CC=C(N5CCN(CC6=C(C7=CC=C(Cl)C=C7)CC(C)(C)CC6)CC5)C=C4OC8=CN=C(NC=C9)C9=C8
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Bcl-2-IN-4 Related Classifications
HY-143872 Related Classifications
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