10161-87-2
10161-87-2
Chemical Structure
KRA-533
- CAS. Nr.: 10161-87-2
- Formula:C13H16BrNO3
- Molecular Weight:314.18
IUPAC Name: 4-(4-(2-bromoacetamido)butyl)benzoic acid
InChIKey: WZQJLTLURXNPQG-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=C(CCCCNC(CBr)=O)C=C1
Biological Activity: KRA-533 is a potent KRAS agonist. KRA-533 binds to the GTP/GDP binding pocket in the KRAS protein to prevent GTP cleavage, resulting in the accumulation of constitutively active GTP-bound KRAS that triggers both apoptotic and autophagic cell death pathways in cancer cells.
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KRA-533 | 98.73% | KRA-533 is a potent KRAS agonist. KRA-533 binds to the GTP/GDP binding pocket in the KRAS protein to prevent GTP cleavage, resulting in the accumulation of constitutively active GTP-bound KRAS that triggers both apoptotic and autophagic cell death pathways in cancer cells. | ||||||||||||||||||||
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