118675-87-9
Chemical Structure
Thymidine 3',5'-diphosphate tetrasodium
Synonym(s): Deoxythymidine 3′,5′-diphosphate tetrasodium; pdTp tetrasodium
- CAS. Nr.: 118675-87-9
- Formula:C10H12N2Na4O11P2
- Molecular Weight:490.12
IUPAC Name: sodium ((2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-(phosphonatooxy)tetrahydrofuran-2-yl)methyl phosphate
InChIKey: VDPDGAPWPLBFIC-ZKRIHRHSSA-J
SMILES: O=C1NC(N([C@@H](C[C@@H]2OP(O[Na])(O[Na])=O)O[C@@H]2COP(O[Na])(O[Na])=O)C=C1C)=O
Biological Activity: Thymidine 3',5'-diphosphate (Deoxythymidine 3′,5′-diphosphate) tetrasodium is a selective inhibitor of staphylococcal nuclease and tudor domain containing 1 (SND1, the MicroRNA regulatory complex RISC subunit) and [3,5-2H2] tyrosyl nuclease. Thymidine 3',5'-diphosphate tetrasodium has anti-tumor activity and can also be used as a catalyst in biochemical reactions[1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Thymidine 3',5'-diphosphate tetrasodium | 98.75% | Thymidine 3',5'-diphosphate (Deoxythymidine 3′,5′-diphosphate) tetrasodium is a selective inhibitor of staphylococcal nuclease and tudor domain containing 1 (SND1, the MicroRNA regulatory complex RISC subunit) and [3,5-2H2] tyrosyl nuclease. Thymidine 3',5'-diphosphate tetrasodium has anti-tumor activity and can also be used as a catalyst in biochemical reactions. | ||||||||||||||||||||
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References
- [1]. Nidhi Jariwala, et al. Oncogenic Role of SND1 in Development and Progression of Hepatocellular Carcinoma. Cancer Res. 2017 Jun 15;77(12):3306-3316. [Content Brief]
- [2]. Cohen J S, et al. Proton magnetic resonance studies of the tyrosine residues of staphylococcal nuclease using [3, 5-2H2] tyrosine[J]. Biochimica et Biophysica Acta (BBA)-Protein Structure, 1971, 236(2): 468-478.
