country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-P12377

Copy Link Print Information

cTP-AlkF-2

cTP-AlkF-2 is a macrocyclic peptide targeting the ganglioside GT1b receptor and can cross the blood-brain barrier. cTP-AlkF-2 induces caveolae-mediated endocytosis/transcytosis, macropinocytosis-mediated internalization, and energy-dependent active transport. cTP-AlkF-2 can serve as a delivery carrier for the synthesis of PVtCD-cTP-AlkF-2 (HY-188196). cTP-AlkF-2 can be used for research on Alzheimer's disease.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₁₀₁H₁₄₁F₁₂N₂₅O₂₆S₂
Molecular Weight:2413.46

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

cTP-AlkF-2 Chemical Structure

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Lysosomal MetabolismOxidative StressAβ/Tau/α-Synuclein AggregationProtein/Amino Acid MetabolismOthers

Lysosomal Metabolism

cTP-AlkF-2 internalizes into hCMEC/D3 cells via caveolae-mediated endocytosis and macropinocytosis^[1].
cTP-AlkF-2 (4 °C) is internalized in brain microvascular endothelial cells mainly through caveolae-mediated endocytosis and macropinocytosis^[2].

Oxidative Stress

cTP-AlkF-2 (24 h) is stable at pH 7.4 in the absence of H₂O₂ and undergoes nearly complete decaging upon ROS triggering^[1].

Oxidative Stress

Aβ/Tau/α-Synuclein Aggregation

Protein/Amino Acid Metabolism

cTP-AlkF-2 (10 μM) selectively reduces total DAPK1 by 62% in Aβ42-exposed SH-SY5Y neurons while not affecting phosphorylated DAPK1^[1].

Others

cTP-AlkF-2 (4 h) shows 11.6-fold higher uptake in hCMEC/D3 cells than the unconjugated DAPK1-binding peptide and 5.6-fold higher uptake than the linear shuttle peptide TP^[1].
cTP-AlkF-2 exhibits enhanced uptake by SH-SY5Y neurons and penetrates the endothelial layer of hCMEC/D3/SH-SY5Y spheroids, accumulating in the neuronal core^[1].
cTP-AlkF-2 (5 µM; 4 h) shows 7.71-fold higher uptake in PC12 cells than FITC-TP^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Alzheimer’s Disease Modeling

Chemical Information

Molecular Weight 2413.46
Formel C₁₀₁H₁₄₁F₁₂N₂₅O₂₆S₂
SMILES

O=C1C(CC(N1CCC(OCC(F)(C(F)(C(F)(C(F)(C(F)(C(F)(COC(CCN2C(CC(C2=O)SC[C@H](N)C(N3)=O)=O)=O)F)F)F)F)F)F)=O)=O)SC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]3CC4=CNC=N4)=O)CC(C)C)=O)CC(N)=O)=O)[C@H](CC)C)=O)CC(C)C)=O)CO)=O)[C@@H](C)O)=O)CC(C)C)=O)CC5=CNC6=CC=CC=C65)=O)CCCCN)=O)CC7=CC=C(O)C=C7)=O)CCCNC(N)=N)=O)C(N)=O
Sequence

Cys-His-Leu-Asn-Ile-Leu-Ser-Thr-Leu-Trp-Lys-Tyr-Arg-Cys-NH2 (cyclo with ALKF-2)
Sequence Shortening

CHLNILSTLWKYRC-NH2 (cyclo with ALKF-2)
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Peng L, et al. Blood-Brain Barrier-Permeable Macrocyclic Chimeras (BmTACs) for Targeted Protein Degradation in the Aging Brain. J Am Chem Soc. 2026;148(38):41137–41150.

[2]. Peng L, et al. A Chemically Engineered Macrocyclic Peptide Shuttle Overcomes Blood-Brain Barrier in Aging Brain. Angewandte Chemie (International ed. in English). 2026 Jan 16;65(3):e20279.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen