Diaplasinin
Based on 1 Customer Validation
Diaplasinin (PAI-749) is a plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 295 nM. Diaplasinin has antithrombotic efficacy.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.87%
- CAS. Nr.: 481631-45-2
- Formel: C32H31N5O
- Molecular Weight:501.62
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
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- Verweise
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Biologische Aktivität
PAI-749 is a potent and selective synthetic antagonist of plasminogen activator inhibitor 1 (PAI-1) that preserved tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA) activities in the presence of PAI-1 (IC50 values, 157 and 87 nM, respectively)[2].
PAI-749 quenches the fluorescence (Fl) of fluorophore-tagged PAI-1 (PAI-NBD119) with the apparent Kd of 254 nM) and the IC50 of 140 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 481631-45-2
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Appearance Solid
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Molecular Weight 501.62
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Formel C32H31N5O
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Color Off-white to light yellow
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SMILES
CCCCCC1=C(N(C2=C1C=CC=C2)CC3=CC=CC=C3)C4=CC=C5C=C(C=CC5=C4)OCC6=NN=NN6
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Synonyms
PAI-749
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 125 mg/mL (249.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. A J Lucking, et al. Effect of the small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor, PAI-749, in clinical models of fibrinolysis. J Thromb Haemost. 2010 Jun;8(6):1333-9. [Content Brief]
[2]. Stephen J Gardell, et al. Neutralization of plasminogen activator inhibitor I (PAI-1) by the synthetic antagonist PAI-749 via a dual mechanism of action. Mol Pharmacol. 2007 Oct;72(4):897-906. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9935 mL | 9.9677 mL | 19.9354 mL | 49.8385 mL |
| 5 mM | 0.3987 mL | 1.9935 mL | 3.9871 mL | 9.9677 mL | |
| 10 mM | 0.1994 mL | 0.9968 mL | 1.9935 mL | 4.9839 mL | |
| 15 mM | 0.1329 mL | 0.6645 mL | 1.3290 mL | 3.3226 mL | |
| 20 mM | 0.0997 mL | 0.4984 mL | 0.9968 mL | 2.4919 mL | |
| 25 mM | 0.0797 mL | 0.3987 mL | 0.7974 mL | 1.9935 mL | |
| 30 mM | 0.0665 mL | 0.3323 mL | 0.6645 mL | 1.6613 mL | |
| 40 mM | 0.0498 mL | 0.2492 mL | 0.4984 mL | 1.2460 mL | |
| 50 mM | 0.0399 mL | 0.1994 mL | 0.3987 mL | 0.9968 mL | |
| 60 mM | 0.0332 mL | 0.1661 mL | 0.3323 mL | 0.8306 mL | |
| 80 mM | 0.0249 mL | 0.1246 mL | 0.2492 mL | 0.6230 mL | |
| 100 mM | 0.0199 mL | 0.0997 mL | 0.1994 mL | 0.4984 mL |
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