Lrp8 - low density lipoprotein receptor-related protein 8, apolipoprotein e receptor Gene

Also Known as Lr8b; ApoER2; 4932703M08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16975

Summary

Enables several functions, including amyloid-beta binding activity; Apolipoprotein binding activity; and reelin receptor activity. Involved in several processes, including nervous system development; positive regulation of CREB transcription factor activity; and regulation of dendrite development. Acts upstream of or within central nervous system development and positive regulation of protein kinase activity. Located in cell surface and extracellular space. Is expressed in nervous system and retina layer. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; dementia; myocardial infarction; and schizophrenia. Orthologous to human LRP8 (LDL receptor related protein 8). [provided by Alliance of Genome Resources, Apr 2022]

Lrp8 Products (6)

mRNA Protein Name
NM_001080926.1 NP_001074395.1 low-density lipoprotein receptor-related protein 8 isoform b precursor
NM_001369051.1 NP_001355980.1 low-density lipoprotein receptor-related protein 8 isoform c precursor
NM_001369052.1 NP_001355981.1 low-density lipoprotein receptor-related protein 8 isoform d
NM_001369053.1 NP_001355982.1 low-density lipoprotein receptor-related protein 8 isoform e
NM_001369054.1 NP_001355983.1 low-density lipoprotein receptor-related protein 8 isoform e
NM_053073.3 NP_444303.2 low-density lipoprotein receptor-related protein 8 isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables amyloid-beta binding IPI
IPI: Inferred from physical interaction
16227578 MGI
enables apolipoprotein binding IDA
IDA: Inferred from direct assay
10571240 MGI
enables calcium-dependent protein binding IPI
IPI: Inferred from physical interaction
10571240 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10571240 MGI
enables reelin receptor activity IDA
IDA: Inferred from direct assay
10571241 MGI
enables reelin receptor activity IMP
IMP: Inferred from mutant phenotype
18778775 MGI
Biological Process GO Annotation Evidence Verweise Source
involved in ammon gyrus development IMP
IMP: Inferred from mutant phenotype
18778775 MGI
involved in chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
18778775 MGI
involved in dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
18778775 MGI
acts upstream of or within hippocampus development IGI
IGI: Inferred from genetic interaction
17330141 MGI
acts upstream of or within layer formation in cerebral cortex IGI
IGI: Inferred from genetic interaction
17330141 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
18778775 MGI
involved in positive regulation of dendrite development IGI
IGI: Inferred from genetic interaction
18778775 MGI
involved in positive regulation of dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
21852430 MGI
acts upstream of or within positive regulation of protein kinase activity IGI
IGI: Inferred from genetic interaction
12526740 MGI
involved in reelin-mediated signaling pathway IDA
IDA: Inferred from direct assay
10571241 MGI
involved in reelin-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
18778775 MGI
involved in regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
29336888 MGI
involved in regulation of innate immune response IMP
IMP: Inferred from mutant phenotype
29336888 MGI
involved in regulation of postsynaptic neurotransmitter receptor activity IDA
IDA: Inferred from direct assay
16102539 MGI
involved in regulation of postsynaptic neurotransmitter receptor activity IMP
IMP: Inferred from mutant phenotype
16102539 MGI
involved in ventral spinal cord development IEP
IEP: Inferred from expression pattern
20711475 MGI
Cellular Component GO Annotation Evidence Verweise Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
16102539 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
16102539 MGI
located in cell surface IDA
IDA: Inferred from direct assay
16227578 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
15950758 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
16102539 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
16102539 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
16102539 MGI
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
16102539 MGI
is active in postsynaptic density membrane IEP
IEP: Inferred from expression pattern
16102539 MGI
is active in postsynaptic density membrane IMP
IMP: Inferred from mutant phenotype
16102539 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

low-density lipoprotein receptor-related protein 8

  • apolipoprotein E receptor 2

  • low density lipoprotein receptor relative, 8 ligand binding repeats, brain

Lrp8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
Lrp8 Q924X6 Dlg4 Mus musculus Q62108
Anti Tag CoIP
16332682
Intra
Lrp8 Q924X6 Grin1 Mus musculus P35438
Anti Bait CoIP
16332682
Intra
Lrp8 Q924X6 Reln Mus musculus Q60841
Anti Bait CoIP
10571241
Intra
Lrp8 Q924X6 Reln Mus musculus Q60841
Pull Down
10571241
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS07802 LRP8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19912 Lrp8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26413 Lrp8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrp8 NCBI NCBI:7804