NES - Nes nestin Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25491

Summary

Enables CCR5 Chemokine Receptor binding activity. Involved in several processes, including positive regulation of intermediate filament depolymerization; positive regulation of neural precursor cell proliferation; and response to ionizing radiation. Located in intermediate filament. Biomarker of acute kidney failure; brain infarction; brain ischemia; and nephrosis. Orthologous to human NES (nestin). [provided by Alliance of Genome Resources, Apr 2022]

NES Products (2)

mRNA Protein Name
NM_001308239.1 NP_001295168.1 nestin isoform 1
NM_012987.2 NP_037119.2 nestin isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables CCR5 chemokine receptor binding IPI
IPI: Inferred from physical interaction
19559698 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in positive regulation of intermediate filament depolymerization IDA
IDA: Inferred from direct assay
12686602 RGD
involved in positive regulation of neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
20510364 RGD
involved in response to ionizing radiation IEP
IEP: Inferred from expression pattern
12445635 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
17065391 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17510525 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in intermediate filament IDA
IDA: Inferred from direct assay
12832492 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nestin

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (20)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-B0193A Prazosin hydrochloride 99.89% Unkown
HY-122272 Paroxetine 99.66% Yes
HY-B0492 Paroxetine hydrochloride 99.98% Unkown
HY-B0527 Amitriptyline 99.94% Yes
HY-B0196 Venlafaxine Inhibitor 99.71% Yes
HY-B0527A Amitriptyline hydrochloride 99.94% Yes
HY-17385 Atomoxetine hydrochloride Inhibitor 99.91% Yes
HY-B0196A Venlafaxine hydrochloride Inhibitor 99.58% Yes
HY-B1110 Nomifensine Inhibitor 98.93% Unkown
HY-B1110A Nomifensine maleate Inhibitor 98.73% Unkown
HY-B0492A Paroxetine hydrochloride hemihydrate 99.96% Unkown
HY-W380450 Viloxazine 99.15% Unkown
HY-125784 Viloxazine hydrochloride Inhibitor 98.94% Unkown
HY-B0527AR Amitriptyline hydrochloride (Standard) 99.03% Unkown
HY-122272R Paroxetine (Standard) 99.79% Unkown
HY-107370 Atomoxetine Inhibitor 98.50% Yes
HY-B0196AR Venlafaxine hydrochloride (Standard) Inhibitor 99.99% Unkown
HY-107370A (Rac)-Atomoxetine hydrochloride Control / Unkown
HY-B0193AR Prazosin hydrochloride (Standard) / Unkown
HY-B0773 Paroxetine mesylate / Unkown

Clinical Phase

Bioactive Molecules (12)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-108039 Bezisterim Inhibitor 95.0% Phase 3
HY-18600 Azimilide Inhibitor 99.01% Phase 3
HY-16736 Centanafadine Inhibitor 99.62% Phase 3
HY-106865 Mivazerol / Phase 3
HY-14472 Tesofensine Inhibitor 99.35% Phase 2
HY-106823 Tebufelone Inhibitor 99.52% Phase 2
HY-U00256 ZD8321 Inhibitor ≥95.0% Phase 2
HY-179566 CHF-6333 Inhibitor / Phase 2
HY-123044 Tedatioxetine Antagonist / Phase 2
HY-15793 NBI-98782 Inhibitor 98.56% Phase 1
HY-101607 KT-362 Antagonist / Phase 1
HY-145487A 5-Hydroxy-6-methoxy (S)-duloxetine maleate Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (92)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-101784 NE 52-QQ57 99.80% Unkown
HY-101484A NE-100 hydrochloride 99.1% Unkown
HY-78932A Dap-NE hydrochloride 99.99% Unkown
HY-N0740 Jatrorrhizine chloride Inhibitor 99.82% Unkown
HY-101323 Olvanil Agonist ≥99.0% Unkown
HY-16011 NE 10790 Inhibitor 99.50% Unkown
HY-78931 Boc-Dap-NE 99.96% Unkown
HY-16736A Centanafadine hydrochloride Inhibitor 99.55% Unkown
HY-18600A Azimilide dihydrochloride Inhibitor 98.17% Unkown
HY-W008794S Normetanephrine-d3 hydrochloride 99.94% Unkown
HY-N0749A Jatrorrhizine hydroxide Inhibitor 98.06% Unkown
HY-P2922 Cathepsin C / Unkown
HY-119541 Ampreloxetine Inhibitor 98.64% Yes
HY-W008794 Normetanephrine hydrochloride 99.69% Unkown
HY-B0196S Venlafaxine-d6 Inhibitor 98.55% Unkown
HY-B0527AS Amitriptyline-d6 hydrochloride 99.93% Unkown
HY-119541A Ampreloxetine TFA 98.30% Unkown
HY-78931A (R,S,S,R,S)-Boc-Dap-NE 97.13% Unkown
HY-B0196AS1 Venlafaxine-d6 hydrochloride Inhibitor 98.18% Unkown
HY-132132 Neutrophil elastase inhibitor 3 Inhibitor 97.23% Unkown
HY-78932G Dap-NE hydrochloride (GMP) / Unkown
HY-101755 Tedatioxetine hydrobromide Antagonist 99.83% Unkown
HY-B0196B (S)-Venlafaxine Inhibitor 98.0% Unkown
HY-N0749 Jatrorrhizine Inhibitor / Unkown
HY-N1745 2'-O-Methylisoliquiritigenin Activator 99.06% Unkown
HY-W112651 2,4,6-Triphenylaniline Inhibitor 95.0% Unkown
HY-W417914 4-Methylamphetamine hydrochloride Agonist 99.86% Unkown
HY-78931B (S,S,S,S,R)-Boc-Dap-NE 99.80% Unkown
HY-78931C (S,S,R,S,R)-Boc-Dap-NE 99.78% Unkown
HY-78931E (R,S,R,S,R)-Boc-Dap-NE 98.74% Unkown
HY-78931F (R,S,S,S,R)-Boc-Dap-NE 99.15% Unkown
HY-78932 Dap-NE 99.49% Unkown
HY-78932C (2S,3R)-Dap-NE hydrochloride Inhibitor / Unkown
HY-W036578 (E)-3-Chlorocinnamaldehyde ≥96.0% Unkown
HY-78931G Boc-Dap-NE (GMP) / Unkown
HY-B1110S Nomifensine-d3 maleate Inhibitor / Unkown
HY-101607A KT-362 free acid Antagonist / Unkown
HY-103247 EMD 66684 Antagonist / Unkown
HY-105330 SIB 1663 Agonist / Unkown
HY-107562 JNJ 10181457 dihydrochloride Antagonist / Unkown
HY-11046 AX-9657 Inhibitor / Unkown
HY-111124 Paroxetine-d2 / Unkown
HY-113933 NE11808 / Unkown
HY-118064 (R)-Thionisoxetine / Unkown
HY-118064A (R)-Thionisoxetine hydrochloride / Unkown
HY-122272S2 Paroxetine-d6-1 / Unkown
HY-122300A Oxaprotiline Inhibitor / Unkown
HY-126825 NE21650 Inhibitor / Unkown
HY-12711 2-Methoxyidazoxan Antagonist / Unkown
HY-129305 Tampramine fumarate Inhibitor / Unkown
HY-129985 Clovoxamine Inhibitor / Unkown
HY-131284 (S)-Dehydro Venlafaxine / Unkown
HY-136860 (R)-Venlafaxine Inhibitor / Unkown
HY-138257 (S)-Indeloxazine benzenesulfonate Inhibitor / Unkown
HY-144246S Zofenoprilat-NES-d5 / Unkown
HY-14472S Tesofensine-d5 Inhibitor / Unkown
HY-14472S1 Tesofensine-13C,d3 Inhibitor / Unkown
HY-17032A Indeloxazine hydrochloride Inhibitor / Unkown
HY-17385S1 Atomoxetine-d7 hydrochloride / Unkown
HY-179566A CHF-6333 xinafoate Inhibitor / Unkown
HY-182465 CHF-6333 chloride Inhibitor / Unkown
HY-182646 NE-10133 Inhibitor / Unkown
HY-18600AS Azimilide-d8 dihydrochloride Inhibitor / Unkown
HY-B0196S1 Venlafaxine-d6-1 Inhibitor 99.9% Unkown
HY-B0196S4 Venlafaxine-d9 / Unkown
HY-N17738 Acetyljujuboside B / Unkown
HY-N6847 5,​6,​7,​40-​Tetrahydroxyisoflavo​ne-​6,​7-​di-​o-​b-​D-​glucopyranoside / Unkown
HY-P10435 KEMPFPKYPVEP Agonist / Unkown
HY-P3064 Scyllatoxin Antagonist / Unkown
HY-P3648 Ala-Ala-Pro-Val-chloromethylketone Inhibitor / Unkown
HY-RS09211 NES Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W061043 DOV-216,303 Inhibitor / Unkown
HY-W681014 5-Fluoro-α-methyltryptamine hydrochloride Activator / Unkown
HY-W700149 N,O-Didesmethylvenlafaxine-d3 / Unkown
HY-W726472 N-(E-4-Coumaroyl)-aspartate / Unkown
HY-W779743 NE58043 / Unkown
HY-106470 Difenamizole / Unkown
HY-107370S Atomoxetine-d7 Inhibitor / Unkown
HY-107370S1 Atomoxetine-d5 / Unkown
HY-11046A KRP-109 / Unkown
HY-117012 NE58018 / Unkown
HY-122272A Paroxetine acetate / Unkown
HY-122272S Paroxetine-d4 / Unkown
HY-138257A (R)-Indeloxazine benzenesulfonate Inhibitor / Unkown
HY-138818 N,O-Didesmethylvenlafaxine / Unkown
HY-78932D (2R,3R)-Dap-NE hydrochloride Inhibitor / Unkown
HY-B0196AS Venlafaxine-d10 hydrochloride Inhibitor / Unkown
HY-B0196S2 Venlafaxine-d4 Inhibitor / Unkown
HY-B0196S3 Venlafaxine-d10 Inhibitor / Unkown
HY-N0740R Jatrorrhizine chloride (Standard) Inhibitor / Unkown
HY-RS17729 Nes Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24194 Nes Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens NES NCBI NCBI:10763