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Cat. No.: HY-113933

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NE11808

NE11808 is a potent antiresorptive bisphosphonate that inhibits osteoclast prenylation and effectively inhibits protein prenylation in osteoclasts and suppresses labeling of dye-front end compounds.

For research use only. We do not sell to patients.

CAS No.: 105462-22-4
Formula: C₇H₁₂N₂O₆P₂
Molecular Weight:282.13

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

NE11808 Chemical Structure

CAS No.: 105462-22-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

NE11808 is a potent antiresorptive bisphosphonate that inhibits osteoclast prenylation and effectively inhibits protein prenylation in osteoclasts and suppresses labeling of dye-front end compounds.

Cellular Effect

Cell Line	Type	Value	Description	References
KB	ED₅₀	144 μM Compound: 74	Dose to inhibit the growth of human KB carcinoma cell line Dose to inhibit the growth of human KB carcinoma cell line	[PMID: 16162013]
MCF7	IC₅₀	223 μM Compound: 35	Antiproliferative activity against human MCF7 cell line by MTT assay Antiproliferative activity against human MCF7 cell line by MTT assay	[PMID: 16970405]
NCI-H460	IC₅₀	63.7 μM Compound: 35	Antiproliferative activity against human NCI-H460 cell line by MTT assay Antiproliferative activity against human NCI-H460 cell line by MTT assay	[PMID: 16970405]
SF-268	IC₅₀	147 μM Compound: 35	Antiproliferative activity against human SF-268 cell line by MTT assay Antiproliferative activity against human SF-268 cell line by MTT assay	[PMID: 16970405]
T-cell	IC₅₀	14 μM Compound: 5	Inhibitory activity, for stimulation of TNF-alpha release in gamma-delta T cells, using a constrained maximum TNF-alpha release of 2700 pg/mL Inhibitory activity, for stimulation of TNF-alpha release in gamma-delta T cells, using a constrained maximum TNF-alpha release of 2700 pg/mL	[PMID: 14711309]
T-cell	IC₅₀	4.8 μM Compound: 5	Inhibitory activity, for stimulation of TNF-alpha release in gamma-delta T cells, using individual observed maximum TNF-alpha release Inhibitory activity, for stimulation of TNF-alpha release in gamma-delta T cells, using individual observed maximum TNF-alpha release	[PMID: 14711309]

Chemical Information

CAS No. 105462-22-4
Molecular Weight 282.13
Formula C₇H₁₂N₂O₆P₂
SMILES

OP(C(P(O)(O)=O)CNC1=NC=CC=C1)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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