NES - nestin Gene
Also Known as Nbla00170
Species: Homo sapiens
About NES
This gene has 1 transcript (splice variant), 91 orthologues and 68 paralogues. Broad expression in heart (RPKM 67.0), fat (RPKM 29.0) and 17 other tissues.
Summary
This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells. [provided by RefSeq, Sep 2011]
NES Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_006617.2 | NP_006608.1 | nestin |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
26496610 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in G2/M transition of mitotic cell cycle |
IDA
IDA: Inferred from direct assay
|
19384922 | GOA |
| involved in negative regulation of catalytic activity |
IDA
IDA: Inferred from direct assay
|
21185309 | GOA |
| involved in negative regulation of protein binding |
IDA
IDA: Inferred from direct assay
|
21185309 | GOA |
| involved in stem cell proliferation |
IMP
IMP: Inferred from mutant phenotype
|
19384922 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
19384922 | GOA |
NES Protein Structure
Filament: Intermediate filament protein (8 - 155)
Filament: Intermediate filament protein (192 - 312)
- 0
- 300
- 600
- 900
- 1200
- 1500
- 1621 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
nestin |
|
NES Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
NES | P48681 | VIM | Homo sapiens | P08670 | 26496610 |
Recombinant NES Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P71762 | NES Protein, Human (P.pastoris, His) | P48681 (P1321-L1569) | ≥ 90%, as determined by reducing SDS-PAGE. |
NES Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81120 | Nestin Antibody | WB, IHC-P, ICC/IF | Human |
| HY-P86694 | Nestin Antibody (YA6386) | IHC-P, IHC-F, IF-Tissue, WB, ICC/IF | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Embryonal Carcinoma |
|
|
| Periventricular Leukomalacia |
|
|
| Central Nervous System Immature Teratoma |
|
|
| Central Neurocytoma |
|
|
| Tuberous Sclerosis |
|
|
| Ganglioglioma |
|
|
| Hydrocephalus Due To Congenital Stenosis Of Aqueduct Of Sylvius |
|
|
| Cellular Ependymoma |
|
|
| Odontoma |
|
|
| Brain Cancer |
|
|
| Teratoma |
|
|
| Glioblastoma |
|
|
| Pilocytic Astrocytoma |
|
|
| Creutzfeldt-Jakob Disease |
|
|
| Zellweger Syndrome |
|
|
| Hydrocephalus |
|
|
| Medulloblastoma |
|
|
| Neurilemmoma |
|
|
| Gliosarcoma |
|
|
| Stork Bite |
|
|
| Medulloepithelioma |
|
|
| Malignant Peripheral Nerve Sheath Tumor |
|
|
| Central Nervous System Primitive Neuroectodermal Neoplasm |
|
|
| Rhabdomyosarcoma |
|
|
| High Grade Glioma |
|
|
| Germ Cell And Embryonal Cancer |
|
|
| Sarcoma, Synovial |
|
|
| Anaplastic Astrocytoma |
|
|
| Pancreatic Cancer |
|
|
| Gliomatosis Cerebri |
|
|
| Gastrointestinal Stromal Tumor |
|
|
| Infratentorial Cancer |
|
|
| Germ Cell Cancer |
|
|
| Developmental And Epileptic Encephalopathy 35 |
|
|
| Basal Cell Carcinoma |
|
|
| Epilepsy |
|
|
| Hypertryptophanemia |
|
|
| Low Grade Glioma |
|
|
| Mixed Glioma |
|
|
| Supratentorial Cancer |
|
|
| Cerebrum Cancer |
|
|
| Central Nervous System Benign Neoplasm |
|
|
| Amyotrophic Lateral Sclerosis 1 |
|
|
| Cerebral Degeneration |
|
|
| Spinal Cord Disease |
|
|
| Stroke, Ischemic |
|
|
| Anaplastic Oligodendroglioma |
|
|
| Diffuse Midline Glioma, H3 K27m-Mutant |
|
|
| Syringomyelia |
|
|
| Ewing Sarcoma |
|
|
| Brain Glioma |
|
|
| Mixed Cerebral Palsy |
|
|
| Melanoma |
|
|
| Neuroblastoma |
|
|
| Spondylometaphyseal Dysplasia With Corneal Dystrophy |
|
|
| Neural Tube Defects |
|
|
| Myopathy |
|
|
| Medullary Colon Carcinoma |
|
|
| Prostate Cancer |
|
|
| Giant Axonal Neuropathy 2 |
|
|
| Congenital Nervous System Abnormality |
|
|
| Hirschsprung Disease 1 |
|
|
| Nervous System Disease |
|
|
| Peripheral Nervous System Disease |
|
|
| Eye Disease |
|
|
| Microcephaly |
|
|
| Retinitis Pigmentosa |
|
|