6-Fluoro-NE
6-Fluoro-NE (6-Fluoro-noradrenaline) is a selective α-adrenergic receptor agonist, with Ki values of 1.2 μM and 0.08 μM for α1 and α2, respectively. 6-Fluoro-NE stimulates phosphoinositide breakdown by activating α1-adrenergic receptor. 6-Fluoro-NE activates α2-adrenergic receptor presynaptically, inhibits nerve stimulation-evoked norepinephrine release, and increases vascular tone postsynaptically. 6-Fluoro-NE can be used for research on cardiovascular diseases and neurological disorders.
For research use only. We do not sell to patients.
- CAS No.: 86820-21-5
- Formula: C8H10FNO3
- Molecular Weight:187.17
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
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α1-adrenergic receptor 1.2 μM (Ki) |
α2-adrenergic receptor 0.08 μM (Ki) |
In Vitro
6-Fluoro-NE inhibits electrically evoked [3H]5HT release in rat hippocampal slices[2].
6-Fluoro-NE (6-FNA) (10 µM), as an α-adrenergic receptor agonist, increases the sPSC frequency of Purkinje neurons to approximately 149% of control in acute cerebellar slices from 14-20 day-old rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mongrel dogs (either sex; 10-22 kg)[5]
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Dosage:1 nM, 10 nM, and 100 nM
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Administration:local i.a. infusion; continuous; started 10-15 min before 2 Hz nerve stimulation and maintained throughout sampling
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Result:Decreased basal vascular conductance by 9% at 1 nM, 34% at 10 nM, and 55% at 100 nM.
At 100 nM, reduced 2 Hz nerve stimulation-evoked noradrenaline overflow by 51%.
Reductions in stimulation-evoked noradrenaline overflow were paralleled by reductions in vasoconstrictor responses, and the effects were fully reversible.
Chemical Information
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CAS No. 86820-21-5
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Molecular Weight 187.17
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Formula C8H10FNO3
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SMILES
FC1=C(C(CN)O)C=C(O)C(O)=C1
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Synonyms
6-Fluoro-noradrenaline
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
6-Fluoro-NE Related Classifications
HY-189047 Related Classifications
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Keywords
- 6-Fluoro-NE
- 86820-21-5
- 6-Fluoro-noradrenaline
- Adrenergic Receptor
- Beta Receptor
- GABAergic synaptic input
- Purkinje neurons
- noradrenaline release
- phosphoinositide breakdown
- serotonin release
- vascular tone
- α-adrenergic agonist
- α1-adrenergic receptor
- α2-adrenergic receptor
- β-adrenergic receptor
- Inhibitor
- inhibitor
- inhibit