PRKD2 - protein kinase D2 Gene

Also Known as PKD2; HSPC187; nPKC-D2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25865

About PRKD2

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:46,674,316-46,717,114 (from NCBI)

This gene has 17 transcripts (splice variants), 190 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 19.7), lymph node (RPKM 14.5) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by Gastrin via the cholecystokinin B receptor (CCKBR) in gastric Cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

PRKD2 Products (4)

mRNA Protein Name
NM_001079880.2 NP_001073349.1 serine/threonine-protein kinase D2 isoform A
NM_001079881.2 NP_001073350.1 serine/threonine-protein kinase D2 isoform A
NM_001079882.2 NP_001073351.1 serine/threonine-protein kinase D2 isoform B
NM_016457.5 NP_057541.2 serine/threonine-protein kinase D2 isoform A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
17962809 GOA
enables protein kinase C binding IPI
IPI: Inferred from physical interaction
28428613 GOA
enables protein kinase activity IDA
IDA: Inferred from direct assay
17077180 GOA
enables protein serine kinase activity IGI
IGI: Inferred from genetic interaction
20497126 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
18440775 GOA
enables protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
28428613 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in T cell receptor signaling pathway IDA
IDA: Inferred from direct assay
17077180 GOA
involved in cellular response to vascular endothelial growth factor stimulus IGI
IGI: Inferred from genetic interaction
20497126 GOA
involved in cellular response to vascular endothelial growth factor stimulus IMP
IMP: Inferred from mutant phenotype
18059339 GOA
involved in intracellular signal transduction IMP
IMP: Inferred from mutant phenotype
18059339 GOA
involved in peptidyl-serine phosphorylation IMP
IMP: Inferred from mutant phenotype
28428613 GOA
involved in peptidyl-threonine phosphorylation IMP
IMP: Inferred from mutant phenotype
28428613 GOA
involved in positive regulation of DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
19192391 GOA
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
15604256 GOA
involved in positive regulation of angiogenesis IGI
IGI: Inferred from genetic interaction
20497126 GOA
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
18440775 GOA
involved in positive regulation of blood vessel endothelial cell migration IGI
IGI: Inferred from genetic interaction
20497126 GOA
involved in positive regulation of blood vessel endothelial cell migration IMP
IMP: Inferred from mutant phenotype
18440775 GOA
involved in positive regulation of cell adhesion IMP
IMP: Inferred from mutant phenotype
17951978 GOA
involved in positive regulation of endothelial cell chemotaxis IGI
IGI: Inferred from genetic interaction
20497126 GOA
involved in positive regulation of endothelial cell chemotaxis IMP
IMP: Inferred from mutant phenotype
18440775 GOA
involved in positive regulation of endothelial cell migration IMP
IMP: Inferred from mutant phenotype
19001381 GOA
involved in positive regulation of endothelial cell proliferation IGI
IGI: Inferred from genetic interaction
20497126 GOA
involved in positive regulation of endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
19001381 GOA
involved in positive regulation of fibroblast growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
19001381 GOA
involved in positive regulation of interleukin-8 production IMP
IMP: Inferred from mutant phenotype
16928771 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17077180 GOA
involved in positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
20497126 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
18059339 GOA
involved in positive regulation of vascular endothelial growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
19001381 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
17077180 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
22228765 GOA
involved in regulation of T cell apoptotic process IMP
IMP: Inferred from mutant phenotype
17077180 GOA
involved in vascular endothelial growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
20497126 GOA
involved in vascular endothelial growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
18059339 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17077180 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17077180 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKD2 Protein Structure

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (139 - 189)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (265 - 314)

PH

PH: PH domain (400 - 477)

Pkinase

Pkinase: Protein kinase domain (555 - 807)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 878 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase D2

PRKD2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
PRKD2 Q9BZL6 HDAC7 Homo sapiens Q8WUI4
Anti Tag CoIP
17962809
Intra
PRKD2 Q9BZL6 HDAC7 Homo sapiens Q8WUI4
Pull Down
17962809
Intra
PRKD2 Q9BZL6 HDAC7 Homo sapiens Q8WUI4
Anti Bait CoIP
17962809
Intra
PRKD2 Q9BZL6 HDAC7 Homo sapiens Q8WUI4
Protein Kinase Assay
17962809
Intra
PRKD2 Q9BZL6 YWHAH Homo sapiens Q04917
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRKD2 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P74615 Protein Kinase D2/PRKD2 Protein, Human (Active, sf9, His-GST) Q9BZL6-1/ NP_057541.2 (M1-L878) ≥ 90%, as determined by reducing SDS-PAGE.

PRKD2 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P81917 Phospho-PRKD2 (Ser876) Antibody (YA1662) WB, IP Human
HY-P81917A Phospho-PRKD2 (Ser876) Antibody (YA1662)(PBS only) WB, IP Human
HY-P81985 PKD2 Antibody (YA1730) WB, IHC-P, ICC/IF, FC Human, Mouse

Related Diseases

Diseases Alias
Angiolipoma
Conventional Lipoma

  • Classic Type Lipoma
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Polycystic Kidney Disease

  • Polycystic Kidney Diseases

  • Pkd

  • Polycystic Renal Disease

  • Kidney Disease, Polycystic

  • Polycystic Kidney, Autosomal Dominant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS11147 PRKD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19475 Prkd2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25968 Prkd2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PRKD2 MGD MGI:2141917
Macaca mulatta PRKD2 VGNC VGNC:76273
Bos taurus PRKD2 VGNC VGNC:33337
Canis familiaris PRKD2 VGNC VGNC:44987
Felis catus PRKD2 VGNC VGNC:64356
Rattus norvegicus PRKD2 RGD RGD:1308054
Others PRKD2 NCBI