CPSF3 - cleavage and polyadenylation specific factor 3 Gene

Also Known as CPSF73; NEDMHS; CPSF-73; NEDMHSN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51692

About CPSF3

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:9,423,654-9,473,101 (from NCBI)

This gene has 5 transcripts (splice variants), 245 orthologues, 3 paralogues and is associated with 1 phenotype. Broad expression in testis (RPKM 20.7), lymph node (RPKM 8.6) and 24 other tissues.

Summary

This gene encodes a member of the metallo-beta-lactamase family. The encoded protein is a 73kDa subunit of the cleavage and polyadenylation specificity factor and functions as an Endonuclease that recognizes the pre-mRNA 3'-cleavage site AAUAAA prior to polyadenylation. It also cleaves after the pre-mRNA sequence ACCCA during histone 3'-end pre-mRNA processing. [provided by RefSeq, Oct 2012]

CPSF3 Products (5)

mRNA Protein Name
NM_001321833.2 NP_001308762.1 cleavage and polyadenylation specificity factor subunit 3 isoform b
NM_001321834.2 NP_001308763.1 cleavage and polyadenylation specificity factor subunit 3 isoform b
NM_001321835.2 NP_001308764.1 cleavage and polyadenylation specificity factor subunit 3 isoform c
NM_001321836.2 NP_001308765.1 cleavage and polyadenylation specificity factor subunit 3 isoform d
NM_016207.4 NP_057291.1 cleavage and polyadenylation specificity factor subunit 3 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables RNA endonuclease activity IMP
IMP: Inferred from mutant phenotype
30507380 GOA
enables metal ion binding IMP
IMP: Inferred from mutant phenotype
30507380 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18288197 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway IDA
IDA: Inferred from direct assay
8929409 GOA
involved in mRNA 3'-end processing IMP
IMP: Inferred from mutant phenotype
30507380 GOA
involved in mRNA 3'-end processing by stem-loop binding and cleavage IDA
IDA: Inferred from direct assay
18688255 GOA
involved in positive regulation of G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
30507380 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of mRNA cleavage and polyadenylation specificity factor complex IDA
IDA: Inferred from direct assay
8929409 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPSF3 Protein Structure

Lactamase_B

Lactamase_B: Metallo-beta-lactamase superfamily (21 - 191)

Beta-Casp

Beta-Casp: Beta-Casp domain (246 - 366)

RMMBL

RMMBL: Zn-dependent metallo-hydrolase RNA specificity domain (381 - 421)

CPSF73-100_C

CPSF73-100_C: Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term (477 - 683)

  • 0
  • 200
  • 400
  • 600
  • 684 a.a.
Protein Preferred Names Protein Names

cleavage and polyadenylation specificity factor subunit 3

  • cleavage and polyadenylation specific factor 3, 73kDa

CPSF3 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P86821 CPSF73 Antibody (YA6514) WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Neurodevelopmental Disorder With Microcephaly, Hypotonia, Nystagmus, And Seizures

  • NEDMHS
Neurodevelopmental Disorder With Hypotonia, Microcephaly, And Seizures

  • NEDHYMS
Oculopharyngeal Muscular Dystrophy

  • OPMD

  • Muscular Dystrophy, Oculopharyngeal

  • Dystrophy, Oculopharyngeal Muscular

  • Oculopharyngeal Dystrophy

  • Progressive Muscular Dystrophy, Oculopharyngeal Type

  • Muscular Dystrophy Oculopharyngeal

  • Dystrophy, Muscular, Oculopharyngeal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-110133 JTE-607 Inhibitor 99.27% Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-153238 AN15368 Inhibitor / Unkown
HY-RS03118 CPSF3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-110133A JTE-607 free base Inhibitor / Unkown
HY-112905 AN11736 Inhibitor / Unkown
HY-RS19423 Cpsf3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25914 Cpsf3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CPSF3 VGNC VGNC:61141
Rattus norvegicus CPSF3 RGD RGD:1305767
Macaca mulatta CPSF3 VGNC VGNC:106142
Mus musculus CPSF3 MGD MGI:1859328
Bos taurus CPSF3 VGNC VGNC:27672
Canis familiaris CPSF3 VGNC VGNC:39575
Others CPSF3 NCBI