Dock2 - dedicator of cyto-kinesis 2 Gene

Also Known as Hch; MBC; CED-5

Species: Mus musculus

Gene Type: protein coding
Gene ID: 94176

Summary

Enables GTPase activator activity. Involved in macropinocytosis; myeloid dendritic cell activation involved in immune response; and positive regulation of phagocytosis. Acts upstream of or within several processes, including T cell activation; immunological synapse formation; and membrane raft polarization. Predicted to be located in cytoplasm; cytoskeleton; and membrane. Is expressed in central nervous system; paraxial mesenchyme; and retina. Human ortholog(s) of this gene implicated in immunodeficiency 40. Orthologous to human DOCK2 (dedicator of cytokinesis 2). [provided by Alliance of Genome Resources, Apr 2022]

Dock2 Products (1)

mRNA Protein Name
NM_033374.3 NP_203538.2 dedicator of cytokinesis protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables GTPase activator activity IMP
IMP: Inferred from mutant phenotype
12871644 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within T cell activation IMP
IMP: Inferred from mutant phenotype
12871644 MGI
acts upstream of or within T cell proliferation IMP
IMP: Inferred from mutant phenotype
12871644 MGI
acts upstream of or within alpha-beta T cell activation IMP
IMP: Inferred from mutant phenotype
12871644 MGI
acts upstream of or within alpha-beta T cell proliferation IMP
IMP: Inferred from mutant phenotype
12871644 MGI
acts upstream of or within chemotaxis IMP
IMP: Inferred from mutant phenotype
11518968 MGI
acts upstream of or within cytoskeleton organization IDA
IDA: Inferred from direct assay
11518968 MGI
acts upstream of or within establishment of T cell polarity IMP
IMP: Inferred from mutant phenotype
12871644 MGI
acts upstream of or within immunological synapse formation IMP
IMP: Inferred from mutant phenotype
12871644 MGI
involved in macropinocytosis IMP
IMP: Inferred from mutant phenotype
21892172 MGI
acts upstream of or within membrane raft polarization IMP
IMP: Inferred from mutant phenotype
12871644 MGI
involved in myeloid dendritic cell activation involved in immune response IMP
IMP: Inferred from mutant phenotype
21892172 MGI
acts upstream of or within negative thymic T cell selection IMP
IMP: Inferred from mutant phenotype
12871644 MGI
involved in positive regulation of phagocytosis IMP
IMP: Inferred from mutant phenotype
21892172 MGI
acts upstream of or within positive thymic T cell selection IMP
IMP: Inferred from mutant phenotype
12871644 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dedicator of cytokinesis protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-111355 Cholesterol sulfate Inhibitor / Unkown
HY-153128 DOCK2-IN-1 Inhibitor 99.37% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dock2 NCBI NCBI:1794