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Art. -Nr.: HY-116488

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IND8

IND8 is a α7 nAChR activator and cognitive enhancer. IND8 mediates cognitive enhancement by activating α7 nAChR . IND8 improves spatial working memory, episodic short-term memory and spatial long-term memory in amnesic mice induced by Scopolamine (HY-N0296). IND8 improves memory function in mice with delayed natural memory decline. IND8 can be used in research related to Alzheimer's disease.

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CAS. Nr.: 1778682-59-9
Formel: C₁₇H₁₉N₅
Molecular Weight:293.37

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

IND8 Chemical Structure

CAS. Nr.: 1778682-59-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

IND8 potently binds to and activates α7-nAChRs in cells expressing LGIC receptors, with a K_d of 0.12 μM and an EC₅₀ of 0.03 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

IND8 (5-50 μmol/kg; i.p.; single administration) rescues scopolamine (HY-N0296)-induced cognitive impairment in male ICR mice, and significantly improves their spatial working memory, episodic short-term memory and spatial reference memory^[1].
IND8 (10-25 μmol/kg; intraperitoneal injection; single administration) improves cognitive function in mice with delayed-induced natural memory decline^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ICR mice (male, 6-weeks of age, scopolamine-induced amnesia)^[1]
Dosage:

5 μmol/kg (1.5 mg/kg); 10 μmol/kg (2.9 mg/kg); 25 μmol/kg (7.3 mg/kg); 50 μmol/kg (14.7 mg/kg)
Administration:

i.p.; single dose
Result:

Significantly reversed scopolamine-induced cognitive deficit, with percentage of unfamiliar arm exploration significantly higher than the scopolamine-treated group.
Increased discrimination index (DI) at 10 μmol/kg and 50 μmol/kg compared to the scopolamine-treated group, and exploration time of the novel object was significantly longer than the familiar object.
Increased time spent in the target quadrant at 25 μmol/kg and 50 μmol/kg compared to the scopolamine-treated group.

Chemical Information

CAS. Nr. 1778682-59-9
Molecular Weight 293.37
Formel C₁₇H₁₉N₅
SMILES

N1(C2CN3CCC2CC3)N=NC(C4=CC5=C(NC=C5)C=C4)=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Arunrungvichian K, et al. Cognitive improvements in a mouse model with substituted 1,2,3-triazole agonists for nicotinic acetylcholine receptors. ACS Chem Neurosci. 2015;6(8):1331-1340. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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