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Art. -Nr.: HY-182783

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JNJ-10450232

(Synonyms: NTM-006)

NTM-006 is a selective and brain-penetrant adenosine A3 receptor (A3AR) agonist. NTM-006 selectively interacts with adenosine A3AR via π-π stacking with Phe168 and π-alkyl interactions receptor residues. NTM-006 inhibits Acetic acid (HY-Y0319)-induced writhing responses in mice. NTM-006 can be used for the research of chronic neuropathic pain, cancer-related pain, osteoarthritis-associated pain.

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CAS. Nr.: 862248-40-6
Formel: C₁₁H₁₁N₃O₂
Molecular Weight:217.22

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

JNJ-10450232 Chemical Structure

CAS. Nr.: 862248-40-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

A3R

Alle Adenosine Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

NTM-006 binds to human full-length A₃AR with a -CDOCKER ENERGY score of 19.31 kcal/mol, via π-π stacking with Phe168 and π-alkyl interactions with select receptor residues^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NTM-006 (30-300 mg/kg, s.c., single dose) shows antinociceptive activity in Acetic acid (HY-Y0319)-induced writhing mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Acetic acid-induced writhing mice (Mus musculus)^[1]
Dosage:

30, 100, 300 mg/kg
Administration:

s.c., single dose
Result:

Inhibited inhibition rate.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 862248-40-6
Molecular Weight 217.22
Formel C₁₁H₁₁N₃O₂
SMILES

CC1=CC(C(NC2=CC=C(O)C=C2)=O)=NN1
Synonyms

NTM-006
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Mu Q, et al. Design, synthesis and evaluation of NTM-006-derived analgesics with enhanced potency. Bioorg Med Chem Lett. Published online March 30, 2026. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

100 mg

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