Nizofenone
Nizofenone is a neuroprotective agent which protects neurons from death following cerebral ischemia or anoxia. Nizofenone can be used in the research of acute neurological conditions, such as stroke.
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- CAS. Nr.: 54533-85-6
- Formel: C21H21ClN4O3
- Molecular Weight:412.87
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
Nizofenone (1 and 10 μM) prolongs the action potential duration of guinea-pig papillary muscle and dog Purkinje fibers[3].
Nizofenone (30 μM) suppresses the spontaneous activity of dog Purkinje fibers and guinea-pigs S-A node[3].
Nizofenone (100 μM) decreases the contractile force of guinea-pig papillary muscle[3].
Nizofenone (10 μM) inhibits the peroxidative disintegration of mitochondria (in rat brain mitochondrial suspension)[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Nizofenone (10 mg/kg i.p.) inhibits ischemia-induced glutamate increase and lactate increase in the hippocampus of rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice with chronic restraint stress[1]
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Dosage:3, 9 mg/kg
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Administration:Intraperitoneal injection (i.p.), daily
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Result:Increased crossing frequencies of the open field test.
Increased in the activities of enzymatic SOD and CAT.
Chemical Information
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CAS. Nr. 54533-85-6
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Molecular Weight 412.87
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Formel C21H21ClN4O3
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SMILES
O=C(C1=C(Cl)C=CC=C1)C2=CC([N+]([O-])=O)=CC=C2N3C=CN=C3CN(CC)CC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Yi Liu, et al. Protective effects of nizofenone administration on the cognitive impairments induced by chronic restraint stress in mice. Pharmacol Biochem Behav. 2013 Jan;103(3):474-80. [Content Brief]
[2]. Y Matsumoto, et al. Nizofenone, a neuroprotective drug, suppresses glutamate release and lactate accumulation. Eur J Pharmacol. 1994 Sep 1;262(1-2):157-61. [Content Brief]
[3]. Y Miura, et al. [Effects of nizofenone on the action potential of guinea-pig papillary muscle and S-A node and dog Purkinje fibers]. [Content Brief]
[4]. H Yasuda, et al. Cerebral protective effect and radical scavenging action. J Neurochem. 1981 Oct;37(4):934-8. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Nizofenone Related Classifications
HY-119513 Related Classifications
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