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Art. -Nr.: HY-121163

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PF-184563

Name: PF-184563
Brand: MedChemExpress
SKU: HY-121163
Price: 888.00 USD
Availability: InStock
Rating: 5 (1 reviews)

Janthitrem F is a metabolite isolated from tremorigen-producing Penicillium and a potential causative agent of ryegrass spurt disease.

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CAS. Nr.: 748806-39-5
Formel: C₂₁H₂₃ClN₆
Molecular Weight:394.90

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

PF-184563 Chemical Structure

CAS. Nr.: 748806-39-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Janthitrem F is a metabolite isolated from tremorigen-producing Penicillium and a potential causative agent of ryegrass spurt disease.

IC₅₀ & Target

Penicillium sp.^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	6.7 nM Compound: 13d, PF-184563	Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay Antagonist activity at human V1A receptor expressed in CHO cells assessed as inhibition of AVP-induced intracellular calcium release after 30 seconds by FLIPR assay	[PMID: 21885275]
HEK293	IC₅₀	17900 nM Compound: 13d, PF-184563	Displacement of [3H]dofetilide from human ERG transfected in HEK293 cells by fluorescence polarization binding assay Displacement of [3H]dofetilide from human ERG transfected in HEK293 cells by fluorescence polarization binding assay	[PMID: 21885275]

Chemical Information

CAS. Nr. 748806-39-5
Molecular Weight 394.90
Formel C₂₁H₂₃ClN₆
SMILES

CN1CC2=CC(Cl)=CC=C2N3C(C4CCN(CC4)C5=NC=CC=C5)=NN=C3C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Discovery of PF-184563, a potent and selective V1a antagonist for the treatment of dysmenorrhoea. The influence of compound flexibility on microsomal stability

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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